Thompson RA - Search Results

1

Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data.

Iegre J, Hayes MA, Thompson RA, Weidolf L, Isin EM. Iegre J, et al. Among authors: thompson ra. Drug Metab Dispos. 2016 May;44(5):732-40. doi: 10.1124/dmd.115.067850. Epub 2016 Feb 11. Drug Metab Dispos. 2016. PMID: 26868617

2

Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies.

Isin EM, Elmore CS, Nilsson GN, Thompson RA, Weidolf L. Isin EM, et al. Among authors: thompson ra. Chem Res Toxicol. 2012 Mar 19;25(3):532-42. doi: 10.1021/tx2005212. Epub 2012 Feb 28. Chem Res Toxicol. 2012. PMID: 22372867

3

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development.

Thompson RA, Isin EM, Li Y, Weaver R, Weidolf L, Wilson I, Claesson A, Page K, Dolgos H, Kenna JG. Thompson RA, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):65-71. doi: 10.1016/j.cbi.2010.11.002. Epub 2010 Nov 11. Chem Biol Interact. 2011. PMID: 21074519

4

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

Thompson RA, Isin EM, Li Y, Weidolf L, Page K, Wilson I, Swallow S, Middleton B, Stahl S, Foster AJ, Dolgos H, Weaver R, Kenna JG. Thompson RA, et al. Chem Res Toxicol. 2012 Aug 20;25(8):1616-32. doi: 10.1021/tx300091x. Epub 2012 May 31. Chem Res Toxicol. 2012. PMID: 22646477

5

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.

Thompson RA, Isin EM, Ogese MO, Mettetal JT, Williams DP. Thompson RA, et al. Chem Res Toxicol. 2016 Apr 18;29(4):505-33. doi: 10.1021/acs.chemrestox.5b00410. Epub 2016 Jan 6. Chem Res Toxicol. 2016. PMID: 26735163 Review.

6

Software-aided structural elucidation in drug discovery.

Ahlqvist M, Leandersson C, Hayes MA, Zamora I, Thompson RA. Ahlqvist M, et al. Among authors: thompson ra. Rapid Commun Mass Spectrom. 2015 Nov 15;29(21):2083-9. doi: 10.1002/rcm.7364. Rapid Commun Mass Spectrom. 2015. PMID: 26443410

7

The metabolic fate of fenclozic acid in chimeric mice with a humanized liver.

Ekdahl A, Weidolf L, Baginski M, Morikawa Y, Thompson RA, Wilson ID. Ekdahl A, et al. Among authors: thompson ra. Arch Toxicol. 2018 Sep;92(9):2819-2828. doi: 10.1007/s00204-018-2274-0. Epub 2018 Aug 9. Arch Toxicol. 2018. PMID: 30094548 Free PMC article.

8

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle.

Plowright AT, Johnstone C, Kihlberg J, Pettersson J, Robb G, Thompson RA. Plowright AT, et al. Among authors: thompson ra. Drug Discov Today. 2012 Jan;17(1-2):56-62. doi: 10.1016/j.drudis.2011.09.012. Epub 2011 Sep 22. Drug Discov Today. 2012. PMID: 21963616 Review.

9

In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery.

Masimirembwa CM, Thompson R, Andersson TB. Masimirembwa CM, et al. Comb Chem High Throughput Screen. 2001 May;4(3):245-63. doi: 10.2174/1386207013331101. Comb Chem High Throughput Screen. 2001. PMID: 11375740 Review.

10

High-throughput screening of pKa values of pharmaceuticals by pressure-assisted capillary electrophoresis and mass spectrometry.

Wan H, Holmén AG, Wang Y, Lindberg W, Englund M, Någård MB, Thompson RA. Wan H, et al. Among authors: thompson ra. Rapid Commun Mass Spectrom. 2003;17(23):2639-48. doi: 10.1002/rcm.1229. Rapid Commun Mass Spectrom. 2003. PMID: 14648902

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