Kelly JW - Search Results

1

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.

Baranczak A, Kelly JW. Baranczak A, et al. Among authors: kelly jw. Curr Opin Chem Biol. 2016 Jun;32:10-21. doi: 10.1016/j.cbpa.2016.01.009. Epub 2016 Feb 6. Curr Opin Chem Biol. 2016. PMID: 26859714 Free PMC article. Review.

2

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Johnson SM, et al. Among authors: kelly jw. Acc Chem Res. 2005 Dec;38(12):911-21. doi: 10.1021/ar020073i. Acc Chem Res. 2005. PMID: 16359163 Review.

3

Beta-sheet folding mechanisms from perturbation energetics.

Deechongkit S, Nguyen H, Jager M, Powers ET, Gruebele M, Kelly JW. Deechongkit S, et al. Among authors: kelly jw. Curr Opin Struct Biol. 2006 Feb;16(1):94-101. doi: 10.1016/j.sbi.2006.01.014. Epub 2006 Jan 25. Curr Opin Struct Biol. 2006. PMID: 16442278 Review.

4

Protein energetics in maturation of the early secretory pathway.

Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. Wiseman RL, et al. Among authors: kelly jw. Curr Opin Cell Biol. 2007 Aug;19(4):359-67. doi: 10.1016/j.ceb.2007.05.005. Epub 2007 Aug 7. Curr Opin Cell Biol. 2007. PMID: 17686625 Free PMC article. Review.

5

Chemical and biological approaches synergize to ameliorate protein-folding diseases.

Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR 3rd, Segatori L, Kelly JW. Mu TW, et al. Among authors: kelly jw. Cell. 2008 Sep 5;134(5):769-81. doi: 10.1016/j.cell.2008.06.037. Cell. 2008. PMID: 18775310 Free PMC article.

6

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. Choi S, et al. Among authors: kelly jw. J Am Chem Soc. 2010 Feb 3;132(4):1359-70. doi: 10.1021/ja908562q. J Am Chem Soc. 2010. PMID: 20043671 Free PMC article.

7

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.

Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Connelly S, et al. Among authors: kelly jw. Curr Opin Struct Biol. 2010 Feb;20(1):54-62. doi: 10.1016/j.sbi.2009.12.009. Epub 2010 Feb 3. Curr Opin Struct Biol. 2010. PMID: 20133122 Free PMC article. Review.

8

Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases.

Ong DS, Kelly JW. Ong DS, et al. Among authors: kelly jw. Curr Opin Cell Biol. 2011 Apr;23(2):231-8. doi: 10.1016/j.ceb.2010.11.002. Epub 2010 Dec 9. Curr Opin Cell Biol. 2011. PMID: 21146391 Free PMC article. Review.

9

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. Johnson SM, et al. Among authors: kelly jw. J Mol Biol. 2012 Aug 10;421(2-3):185-203. doi: 10.1016/j.jmb.2011.12.060. Epub 2012 Jan 5. J Mol Biol. 2012. PMID: 22244854 Free PMC article. Review.

10

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Grimster NP, et al. Among authors: kelly jw. J Am Chem Soc. 2013 Apr 17;135(15):5656-68. doi: 10.1021/ja311729d. Epub 2013 Feb 14. J Am Chem Soc. 2013. PMID: 23350654 Free PMC article.

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