Torka R - Search Results

1

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo.

Onken J, Torka R, Korsing S, Radke J, Krementeskaia I, Nieminen M, Bai X, Ullrich A, Heppner F, Vajkoczy P. Onken J, et al. Among authors: torka r. Oncotarget. 2016 Mar 1;7(9):9876-89. doi: 10.18632/oncotarget.7130. Oncotarget. 2016. PMID: 26848524 Free PMC article.

2

Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival.

Onken J, Vajkoczy P, Torka R, Hempt C, Patsouris V, Heppner FL, Radke J. Onken J, et al. Among authors: torka r. Oncotarget. 2017 Jun 13;8(31):50403-50414. doi: 10.18632/oncotarget.18468. eCollection 2017 Aug 1. Oncotarget. 2017. PMID: 28881571 Free PMC article.

3

Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy.

Torka R, Pénzes K, Gusenbauer S, Baumann C, Szabadkai I, Őrfi L, Kéri G, Ullrich A. Torka R, et al. Neoplasia. 2014 Apr;16(4):301-18. doi: 10.1016/j.neo.2014.03.009. Neoplasia. 2014. PMID: 24862757 Free PMC article.

4

Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells.

Pénzes K, Baumann C, Szabadkai I, Orfi L, Kéri G, Ullrich A, Torka R. Pénzes K, et al. Among authors: torka r. Cancer Biol Ther. 2014;15(11):1571-82. doi: 10.4161/15384047.2014.956634. Cancer Biol Ther. 2014. PMID: 25482942 Free PMC article.

5

GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.

Baumann C, Ullrich A, Torka R. Baumann C, et al. Among authors: torka r. Mol Oncol. 2017 Oct;11(10):1430-1447. doi: 10.1002/1878-0261.12109. Epub 2017 Jul 26. Mol Oncol. 2017. PMID: 28675785 Free PMC article.

6

Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors.

Szabadkai I, Torka R, Garamvölgyi R, Baska F, Gyulavári P, Boros S, Illyés E, Choidas A, Ullrich A, Őrfi L. Szabadkai I, et al. Among authors: torka r. J Med Chem. 2018 Jul 26;61(14):6277-6292. doi: 10.1021/acs.jmedchem.8b00672. Epub 2018 Jul 9. J Med Chem. 2018. PMID: 29928803

7

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM. Paolino M, et al. Among authors: torka r. Nature. 2014 Mar 27;507(7493):508-12. doi: 10.1038/nature12998. Epub 2014 Feb 19. Nature. 2014. PMID: 24553136 Free PMC article.

8

Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue.

Orfi Z, Waczek F, Baska F, Szabadkai I, Torka R, Hartmann J, Orfi L, Ullrich A. Orfi Z, et al. Among authors: torka r. Sci Rep. 2017 Mar 8;7:44073. doi: 10.1038/srep44073. Sci Rep. 2017. PMID: 28272433 Free PMC article.

9

Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors.

Szokol B, Gyulavári P, Kurkó I, Baska F, Szántai-Kis C, Greff Z, Orfi Z, Peták I, Pénzes K, Torka R, Ullrich A, Orfi L, Vántus T, Kéri G. Szokol B, et al. Among authors: torka r. ACS Med Chem Lett. 2014 Jan 30;5(4):298-303. doi: 10.1021/ml4003309. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900830 Free PMC article.

10

Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation.

Lauter M, Weber A, Torka R. Lauter M, et al. Among authors: torka r. Cell Commun Signal. 2019 Jun 6;17(1):59. doi: 10.1186/s12964-019-0377-8. Cell Commun Signal. 2019. PMID: 31171001 Free PMC article.

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