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Mitochondria are required for pro-ageing features of the senescent phenotype.
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Correia-Melo C, et al. Among authors: greaves l. EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4. EMBO J. 2016. PMID: 26848154 Free PMC article.
The ageing mitochondrial genome.
Krishnan KJ, Greaves LC, Reeve AK, Turnbull D. Krishnan KJ, et al. Nucleic Acids Res. 2007;35(22):7399-405. doi: 10.1093/nar/gkm635. Epub 2007 Oct 2. Nucleic Acids Res. 2007. PMID: 17913753 Free PMC article. Review.
Mitochondrial DNA mutations and ageing.
Greaves LC, Turnbull DM. Greaves LC, et al. Biochim Biophys Acta. 2009 Oct;1790(10):1015-20. doi: 10.1016/j.bbagen.2009.04.018. Epub 2009 May 4. Biochim Biophys Acta. 2009. PMID: 19409965 Review.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.
Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Jurk D, et al. Among authors: greaves l. Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172. Nat Commun. 2014. PMID: 24960204 Free PMC article.
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Anderson R, et al. Among authors: greaves lc. EMBO J. 2019 Mar 1;38(5):e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. EMBO J. 2019. PMID: 30737259 Free PMC article.
Aberrant mitochondrial function in ageing and cancer.
Whitehall JC, Greaves LC. Whitehall JC, et al. Biogerontology. 2020 Aug;21(4):445-459. doi: 10.1007/s10522-019-09853-y. Epub 2019 Dec 4. Biogerontology. 2020. PMID: 31802313 Free PMC article. Review.
Mitochondrial DNA mutations in ageing and cancer.
Smith ALM, Whitehall JC, Greaves LC. Smith ALM, et al. Among authors: greaves lc. Mol Oncol. 2022 Sep;16(18):3276-3294. doi: 10.1002/1878-0261.13291. Epub 2022 Jul 28. Mol Oncol. 2022. PMID: 35842901 Free PMC article. Review.
Mitochondrial DNA Mutations and Ageing.
Whitehall JC, Smith ALM, Greaves LC. Whitehall JC, et al. Among authors: greaves lc. Subcell Biochem. 2023;102:77-98. doi: 10.1007/978-3-031-21410-3_4. Subcell Biochem. 2023. PMID: 36600130
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: greaves lc. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
181 results