Cohen JB - Search Results

1

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G. Eaton MM, et al. Among authors: cohen jb. Curr Neuropharmacol. 2016;14(7):772-80. doi: 10.2174/1570159x14666160202121319. Curr Neuropharmacol. 2016. PMID: 26830963 Free PMC article. Review.

2

Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.

Li GD, Chiara DC, Cohen JB, Olsen RW. Li GD, et al. Among authors: cohen jb. J Biol Chem. 2010 Mar 19;285(12):8615-20. doi: 10.1074/jbc.M109.074708. Epub 2010 Jan 18. J Biol Chem. 2010. PMID: 20083606 Free PMC article.

3

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

Li GD, Chiara DC, Sawyer GW, Husain SS, Olsen RW, Cohen JB. Li GD, et al. Among authors: cohen jb. J Neurosci. 2006 Nov 8;26(45):11599-605. doi: 10.1523/JNEUROSCI.3467-06.2006. J Neurosci. 2006. PMID: 17093081 Free PMC article.

4

Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.

Li GD, Chiara DC, Cohen JB, Olsen RW. Li GD, et al. Among authors: cohen jb. J Biol Chem. 2009 May 1;284(18):11771-5. doi: 10.1074/jbc.C900016200. Epub 2009 Mar 12. J Biol Chem. 2009. PMID: 19282280 Free PMC article.

5

Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Jayakar SS, et al. Among authors: cohen jb. J Biol Chem. 2014 Oct 3;289(40):27456-68. doi: 10.1074/jbc.M114.581728. Epub 2014 Aug 1. J Biol Chem. 2014. PMID: 25086038 Free PMC article.

6

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Wu B, et al. Among authors: cohen jb. Eur J Med Chem. 2019 Jan 15;162:810-824. doi: 10.1016/j.ejmech.2018.11.019. Epub 2018 Nov 19. Eur J Med Chem. 2019. PMID: 30544077 Free PMC article.

7

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Jayakar SS, et al. Among authors: cohen jb. J Biol Chem. 2015 Sep 18;290(38):23432-46. doi: 10.1074/jbc.M115.672006. Epub 2015 Jul 30. J Biol Chem. 2015. PMID: 26229099 Free PMC article.

8

Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABA_A) receptors.

Jayakar SS, Chiara DC, Zhou X, Wu B, Bruzik KS, Miller KW, Cohen JB. Jayakar SS, et al. Among authors: cohen jb. J Biol Chem. 2020 Aug 14;295(33):11495-11512. doi: 10.1074/jbc.RA120.013452. Epub 2020 Jun 15. J Biol Chem. 2020. PMID: 32540960 Free PMC article.

9

Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

Sawyer GW, Chiara DC, Olsen RW, Cohen JB. Sawyer GW, et al. Among authors: cohen jb. J Biol Chem. 2002 Dec 20;277(51):50036-45. doi: 10.1074/jbc.M209281200. Epub 2002 Oct 17. J Biol Chem. 2002. PMID: 12388542 Free article.

10

Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Chiara DC, et al. Among authors: cohen jb. Biochemistry. 2012 Jan 31;51(4):836-47. doi: 10.1021/bi201772m. Epub 2012 Jan 23. Biochemistry. 2012. PMID: 22243422 Free PMC article.

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