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Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.
Williams JR, Trias E, Beilby PR, Lopez NI, Labut EM, Bradford CS, Roberts BR, McAllum EJ, Crouch PJ, Rhoads TW, Pereira C, Son M, Elliott JL, Franco MC, Estévez AG, Barbeito L, Beckman JS. Williams JR, et al. Neurobiol Dis. 2016 May;89:1-9. doi: 10.1016/j.nbd.2016.01.020. Epub 2016 Jan 27. Neurobiol Dis. 2016. PMID: 26826269 Free PMC article.
Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.
Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Lim SC, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty JF, Llanos RM, Kramer DR, Mercer JF, Bush AI, Masters CL, Duce JA, Li QX, Beckman JS, Barnham KJ, White AR, Crouch PJ. Roberts BR, et al. Among authors: williams jr. J Neurosci. 2014 Jun 4;34(23):8021-31. doi: 10.1523/JNEUROSCI.4196-13.2014. J Neurosci. 2014. PMID: 24899723 Free PMC article.
Biomarkers.
DeConne TM, Williams JR, Pewowaruk R, Korcarz CE, Tanley JE, Carlsson CM, Heckbert SR, Habes M, Nasrallah IM, Lockhart SN, Luchsinger JA, Ding J, Liu Y, Hayden KM, Gepner AD, Hughes TM. DeConne TM, et al. Among authors: williams jr. Alzheimers Dement. 2024 Dec;20 Suppl 2(Suppl 2):e089226. doi: 10.1002/alz.089226. Alzheimers Dement. 2024. PMID: 39784469 Free PMC article.
3,275 results