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539 results

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Page 1
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes.
Schug M, Stöber R, Heise T, Mielke H, Gundert-Remy U, Godoy P, Reif R, Blaszkewicz M, Ellinger-Ziegelbauer H, Ahr HJ, Selinski S, Günther G, Marchan R, Blaszkewicz M, Sachinidis A, Nüssler A, Oberemm A, Hengstler JG. Schug M, et al. Among authors: godoy p. Arch Toxicol. 2013 Feb;87(2):337-45. doi: 10.1007/s00204-012-0999-8. Epub 2012 Dec 29. Arch Toxicol. 2013. PMID: 23274394
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.
Campos G, Schmidt-Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas DB, Hetz C, Widera A, Cadenas C, Begher-Tibbe B, Reif R, Günther G, Sachinidis A, Hengstler JG, Godoy P. Campos G, et al. Among authors: godoy p. Arch Toxicol. 2014 Jun;88(6):1267-80. doi: 10.1007/s00204-014-1240-8. Epub 2014 Apr 20. Arch Toxicol. 2014. PMID: 24748426
Toxicogenomics directory of chemically exposed human hepatocytes.
Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG. Grinberg M, et al. Among authors: godoy p. Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16. Arch Toxicol. 2014. PMID: 25399406
Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests.
Shinde V, Hoelting L, Srinivasan SP, Meisig J, Meganathan K, Jagtap S, Grinberg M, Liebing J, Bluethgen N, Rahnenführer J, Rempel E, Stoeber R, Schildknecht S, Förster S, Godoy P, van Thriel C, Gaspar JA, Hescheler J, Waldmann T, Hengstler JG, Leist M, Sachinidis A. Shinde V, et al. Among authors: godoy p. Arch Toxicol. 2017 Feb;91(2):839-864. doi: 10.1007/s00204-016-1741-8. Epub 2016 May 17. Arch Toxicol. 2017. PMID: 27188386 Free PMC article.
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG. Godoy P, et al. Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23. Arch Toxicol. 2016. PMID: 27339419 Free PMC article.
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Gu X, Albrecht W, Edlund K, Kappenberg F, Rahnenführer J, Leist M, Moritz W, Godoy P, Cadenas C, Marchan R, Brecklinghaus T, Pardo LT, Castell JV, Gardner I, Han B, Hengstler JG, Stoeber R. Gu X, et al. Among authors: godoy p. Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13. Arch Toxicol. 2018. PMID: 30317417
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG. Grinberg M, et al. Among authors: godoy p. Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3. Arch Toxicol. 2018. PMID: 30511339
539 results