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Page 1
Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
Grace CR, Ban D, Min J, Mayasundari A, Min L, Finch KE, Griffiths L, Bharatham N, Bashford D, Kiplin Guy R, Dyer MA, Kriwacki RW. Grace CR, et al. Among authors: kiplin guy r. J Mol Biol. 2016 Mar 27;428(6):1290-1303. doi: 10.1016/j.jmb.2016.01.016. Epub 2016 Jan 23. J Mol Biol. 2016. PMID: 26812210 Free PMC article.
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Shadrick WR, Slavish PJ, Chai SC, Waddell B, Connelly M, Low JA, Tallant C, Young BM, Bharatham N, Knapp S, Boyd VA, Morfouace M, Roussel MF, Chen T, Lee RE, Kiplin Guy R, Shelat AA, Potter PM. Shadrick WR, et al. Among authors: kiplin guy r. Bioorg Med Chem. 2018 Jan 1;26(1):25-36. doi: 10.1016/j.bmc.2017.10.042. Epub 2017 Nov 4. Bioorg Med Chem. 2018. PMID: 29170024 Free PMC article.
Diverse amide analogs of sulindac for cancer treatment and prevention.
Mathew B, Hobrath JV, Connelly MC, Kiplin Guy R, Reynolds RC. Mathew B, et al. Among authors: kiplin guy r. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4614-4621. doi: 10.1016/j.bmcl.2017.09.022. Epub 2017 Sep 13. Bioorg Med Chem Lett. 2017. PMID: 28935266 Free PMC article.
Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein.
Eagon S, Hammill JT, Bach J, Everson N, Sisley TA, Walls MJ, Durham S, Pillai DR, Falade MO, Rice AL, Kimball JJ, Lazaro H, DiBernardo C, Kiplin Guy R. Eagon S, et al. Among authors: kiplin guy r. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127502. doi: 10.1016/j.bmcl.2020.127502. Epub 2020 Aug 18. Bioorg Med Chem Lett. 2020. PMID: 32822760 Free article.