Ghosh P - Search Results

1

The untapped potential of tyrosine-based G protein signaling.

Ghosh P. Ghosh P. Pharmacol Res. 2016 Mar;105:99-107. doi: 10.1016/j.phrs.2016.01.017. Epub 2016 Jan 22. Pharmacol Res. 2016. PMID: 26808081 Free PMC article. Review.

2

Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.

Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P. Mittal Y, et al. Among authors: ghosh p. J Biol Chem. 2011 Sep 16;286(37):32404-15. doi: 10.1074/jbc.M111.275685. Epub 2011 Jul 28. J Biol Chem. 2011. PMID: 21799016 Free PMC article.

3

Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling.

Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG. Garcia-Marcos M, et al. Among authors: ghosh p. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1961-6. doi: 10.1073/pnas.1120538109. Epub 2012 Jan 25. Proc Natl Acad Sci U S A. 2012. PMID: 22308453 Free PMC article.

4

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. Lin C, et al. Among authors: ghosh p. Mol Biol Cell. 2014 Nov 5;25(22):3654-71. doi: 10.1091/mbc.E14-05-0978. Epub 2014 Sep 3. Mol Biol Cell. 2014. PMID: 25187647 Free PMC article.

5

GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.

Garcia-Marcos M, Ghosh P, Farquhar MG. Garcia-Marcos M, et al. Among authors: ghosh p. J Biol Chem. 2015 Mar 13;290(11):6697-704. doi: 10.1074/jbc.R114.613414. Epub 2015 Jan 20. J Biol Chem. 2015. PMID: 25605737 Free PMC article. Review.

6

Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. Midde KK, et al. Among authors: ghosh p. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E937-46. doi: 10.1073/pnas.1420140112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25713130 Free PMC article.

7

Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.

Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P. Lo IC, et al. Among authors: ghosh p. Dev Cell. 2015 Apr 20;33(2):189-203. doi: 10.1016/j.devcel.2015.02.009. Epub 2015 Apr 9. Dev Cell. 2015. PMID: 25865347 Free PMC article.

8

Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.

Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel Y, Gallo RL, Ghosh P. Ma GS, et al. Among authors: ghosh p. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2602-10. doi: 10.1073/pnas.1505543112. Epub 2015 Apr 29. Proc Natl Acad Sci U S A. 2015. PMID: 25926659 Free PMC article.

9

G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron.

Ghosh P. Ghosh P. Cell Cycle. 2015;14(16):2561-5. doi: 10.1080/15384101.2015.1066538. Epub 2015 Jun 30. Cell Cycle. 2015. PMID: 26126131 Free PMC article.

10

Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a Hydra.

Ghosh P. Ghosh P. Aging (Albany NY). 2015 Jul;7(7):469-74. doi: 10.18632/aging.100781. Aging (Albany NY). 2015. PMID: 26224586 Free PMC article. Review.

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