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A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.
Meunier I, Lenaers G, Bocquet B, Baudoin C, Piro-Megy C, Cubizolle A, Quilès M, Jean-Charles A, Cohen SY, Merle H, Gaudric A, Labesse G, Manes G, Péquignot M, Cazevieille C, Dhaenens CM, Fichard A, Ronkina N, Arthur SJ, Gaestel M, Hamel CP. Meunier I, et al. Among authors: gaestel m. Hum Mol Genet. 2016 Mar 1;25(5):916-26. doi: 10.1093/hmg/ddv624. Epub 2016 Jan 6. Hum Mol Genet. 2016. PMID: 26744326
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB. Ronkina N, et al. Among authors: gaestel m. Mol Cell Biol. 2007 Jan;27(1):170-81. doi: 10.1128/MCB.01456-06. Epub 2006 Oct 9. Mol Cell Biol. 2007. PMID: 17030606 Free PMC article.
MK2 and MK3--a pair of isoenzymes?
Ronkina N, Kotlyarov A, Gaestel M. Ronkina N, et al. Among authors: gaestel m. Front Biosci. 2008 May 1;13:5511-21. doi: 10.2741/3095. Front Biosci. 2008. PMID: 18508601 Review.
Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG. Ehlting C, et al. Among authors: gaestel m. J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17. J Biol Chem. 2011. PMID: 21586572 Free PMC article.
273 results