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Thrombin stimulates insulin secretion via protease-activated receptor-3.
Hänzelmann S, Wang J, Güney E, Tang Y, Zhang E, Axelsson AS, Nenonen H, Salehi AS, Wollheim CB, Zetterberg E, Berntorp E, Costa IG, Castelo R, Rosengren AH. Hänzelmann S, et al. Among authors: costa ig. Islets. 2015;7(4):e1118195. doi: 10.1080/19382014.2015.1118195. Islets. 2015. PMID: 26742564 Free PMC article.
Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites.
Hänzelmann S, Beier F, Gusmao EG, Koch CM, Hummel S, Charapitsa I, Joussen S, Benes V, Brümmendorf TH, Reid G, Costa IG, Wagner W. Hänzelmann S, et al. Among authors: costa ig. Clin Epigenetics. 2015 Mar 4;7(1):19. doi: 10.1186/s13148-015-0057-5. eCollection 2015. Clin Epigenetics. 2015. PMID: 25763115 Free PMC article.
Epigenetic program and transcription factor circuitry of dendritic cell development.
Lin Q, Chauvistré H, Costa IG, Gusmao EG, Mitzka S, Hänzelmann S, Baying B, Klisch T, Moriggl R, Hennuy B, Smeets H, Hoffmann K, Benes V, Seré K, Zenke M. Lin Q, et al. Among authors: costa ig. Nucleic Acids Res. 2015 Nov 16;43(20):9680-93. doi: 10.1093/nar/gkv1056. Epub 2015 Oct 17. Nucleic Acids Res. 2015. PMID: 26476451 Free PMC article.
Mtss1 is a critical epigenetically regulated tumor suppressor in CML.
Schemionek M, Herrmann O, Reher MM, Chatain N, Schubert C, Costa IG, Hänzelmann S, Gusmao EG, Kintsler S, Braunschweig T, Hamilton A, Helgason GV, Copland M, Schwab A, Müller-Tidow C, Li S, Holyoake TL, Brümmendorf TH, Koschmieder S. Schemionek M, et al. Among authors: costa ig. Leukemia. 2016 Apr;30(4):823-32. doi: 10.1038/leu.2015.329. Epub 2015 Dec 1. Leukemia. 2016. PMID: 26621336 Free article.
The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation.
Kalwa M, Hänzelmann S, Otto S, Kuo CC, Franzen J, Joussen S, Fernandez-Rebollo E, Rath B, Koch C, Hofmann A, Lee SH, Teschendorff AE, Denecke B, Lin Q, Widschwendter M, Weinhold E, Costa IG, Wagner W. Kalwa M, et al. Among authors: costa ig. Nucleic Acids Res. 2016 Dec 15;44(22):10631-10643. doi: 10.1093/nar/gkw802. Epub 2016 Sep 14. Nucleic Acids Res. 2016. PMID: 27634931 Free PMC article.
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH. Axelsson AS, et al. Among authors: costa ig. Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652. Nat Commun. 2017. PMID: 28585545 Free PMC article.
Detection of RNA-DNA binding sites in long noncoding RNAs.
Kuo CC, Hänzelmann S, Sentürk Cetin N, Frank S, Zajzon B, Derks JP, Akhade VS, Ahuja G, Kanduri C, Grummt I, Kurian L, Costa IG. Kuo CC, et al. Among authors: costa ig. Nucleic Acids Res. 2019 Apr 8;47(6):e32. doi: 10.1093/nar/gkz037. Nucleic Acids Res. 2019. PMID: 30698727 Free PMC article.
Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms.
Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Denecke B, Han L, Küstermann C, Sontag S, Seré K, Strathmann K, Zenke M, Schuppert A, Brümmendorf TH, Kranc KR, Koschmieder S, Gezer D. Baumeister J, et al. Among authors: costa ig. Leukemia. 2020 Apr;34(4):1062-1074. doi: 10.1038/s41375-019-0629-z. Epub 2019 Nov 14. Leukemia. 2020. PMID: 31728053
CrossTalkeR: analysis and visualization of ligand-receptorne tworks.
Nagai JS, Leimkühler NB, Schaub MT, Schneider RK, Costa IG. Nagai JS, et al. Among authors: costa ig. Bioinformatics. 2021 Nov 18;37(22):4263-4265. doi: 10.1093/bioinformatics/btab370. Bioinformatics. 2021. PMID: 35032393 Free PMC article.
149 results