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Genetic variation at a single locus and age of onset for Alzheimer's disease.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Lutz MW, et al. Among authors: roses ad. Alzheimers Dement. 2010 Mar;6(2):125-31. doi: 10.1016/j.jalz.2010.01.011. Alzheimers Dement. 2010. PMID: 20298972 Free PMC article.
The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is associated with the age of onset of LOAD [Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, et al. A …
The significant finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is …
The importance of being connected.
Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Lutz MW, et al. Among authors: roses ad. J Alzheimers Dis. 2011;24(2):247-51. doi: 10.3233/JAD-2010-101765. J Alzheimers Dis. 2011. PMID: 21206004 Free article. No abstract available.
The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.
Linnertz C, Anderson L, Gottschalk W, Crenshaw D, Lutz MW, Allen J, Saith S, Mihovilovic M, Burke JR, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. Linnertz C, et al. Among authors: roses ad. Alzheimers Dement. 2014 Sep;10(5):541-51. doi: 10.1016/j.jalz.2013.08.280. Epub 2014 Jan 15. Alzheimers Dement. 2014. PMID: 24439168 Free PMC article.
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.
Greenbaum L, Springer RR, Lutz MW, Heymann A, Lubitz I, Cooper I, Kravitz E, Sano M, Roses AD, Silverman JM, Saunders AM, Beeri MS. Greenbaum L, et al. Among authors: roses ad. Eur Neuropsychopharmacol. 2014 Sep;24(9):1492-9. doi: 10.1016/j.euroneuro.2014.06.002. Epub 2014 Jun 13. Eur Neuropsychopharmacol. 2014. PMID: 25044051 Free PMC article.
462 results