Duan D - Search Results

1

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

Nelson CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Castellanos Rivera RM, Madhavan S, Pan X, Ran FA, Yan WX, Asokan A, Zhang F, Duan D, Gersbach CA. Nelson CE, et al. Among authors: duan d. Science. 2016 Jan 22;351(6271):403-7. doi: 10.1126/science.aad5143. Epub 2015 Dec 31. Science. 2016. PMID: 26721684 Free PMC article.

2

Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy.

Harper SQ, Hauser MA, DelloRusso C, Duan D, Crawford RW, Phelps SF, Harper HA, Robinson AS, Engelhardt JF, Brooks SV, Chamberlain JS. Harper SQ, et al. Among authors: duan d. Nat Med. 2002 Mar;8(3):253-61. doi: 10.1038/nm0302-253. Nat Med. 2002. PMID: 11875496

3

Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart.

Yue Y, Li Z, Harper SQ, Davisson RL, Chamberlain JS, Duan D. Yue Y, et al. Among authors: duan d. Circulation. 2003 Sep 30;108(13):1626-32. doi: 10.1161/01.CIR.0000089371.11664.27. Epub 2003 Sep 2. Circulation. 2003. PMID: 12952841 Free PMC article.

4

Full-length dystrophin expression in half of the heart cells ameliorates beta-isoproterenol-induced cardiomyopathy in mdx mice.

Yue Y, Skimming JW, Liu M, Strawn T, Duan D. Yue Y, et al. Among authors: duan d. Hum Mol Genet. 2004 Aug 1;13(15):1669-75. doi: 10.1093/hmg/ddh174. Epub 2004 Jun 9. Hum Mol Genet. 2004. PMID: 15190010 Free PMC article.

5

Trans-splicing adeno-associated viral vector-mediated gene therapy is limited by the accumulation of spliced mRNA but not by dual vector coinfection efficiency.

Xu Z, Yue Y, Lai Y, Ye C, Qiu J, Pintel DJ, Duan D. Xu Z, et al. Among authors: duan d. Hum Gene Ther. 2004 Sep;15(9):896-905. doi: 10.1089/hum.2004.15.896. Hum Gene Ther. 2004. PMID: 15353044 Free PMC article.

6

Synthetic intron improves transduction efficiency of trans-splicing adeno-associated viral vectors.

Lai Y, Yue Y, Liu M, Duan D. Lai Y, et al. Among authors: duan d. Hum Gene Ther. 2006 Oct;17(10):1036-42. doi: 10.1089/hum.2006.17.1036. Hum Gene Ther. 2006. PMID: 17007565 Free PMC article.

We have shown that rational selection of the gene-splitting site in a therapeutic target gene can lead to extremely efficient trans-splicing vectors [Lai, Y., Yue, Y., Liu, M., Ghosh, A., Engelhardt, J.F., Chamberlain, J.S., and Duan, D. (2005). Nat. Biotechnol. 23, …

We have shown that rational selection of the gene-splitting site in a therapeutic target gene can lead to extremely efficient trans-splicing …

7

From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy.

Duan D. Duan D. Discov Med. 2006 Jun;6(33):103-8. Discov Med. 2006. PMID: 17234143 Free PMC article.

8

Efficient whole-body transduction with trans-splicing adeno-associated viral vectors.

Ghosh A, Yue Y, Long C, Bostick B, Duan D. Ghosh A, et al. Among authors: duan d. Mol Ther. 2007 Apr;15(4):750-5. doi: 10.1038/sj.mt.6300081. Epub 2007 Jan 30. Mol Ther. 2007. PMID: 17264855 Free PMC article.

9

Myodys, a full-length dystrophin plasmid vector for Duchenne and Becker muscular dystrophy gene therapy.

Duan D. Duan D. Curr Opin Mol Ther. 2008 Feb;10(1):86-94. Curr Opin Mol Ther. 2008. PMID: 18228186

10

Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.

Bostick B, Yue Y, Lai Y, Long C, Li D, Duan D. Bostick B, et al. Among authors: duan d. Hum Gene Ther. 2008 Aug;19(8):851-6. doi: 10.1089/hum.2008.058. Hum Gene Ther. 2008. PMID: 18666839 Free PMC article.

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