Greenfield MT - Search Results

1

Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.

Zech SG, Kohlmann A, Zhou T, Li F, Squillace RM, Parillon LE, Greenfield MT, Miller DP, Qi J, Thomas RM, Wang Y, Xu Y, Miret JJ, Shakespeare WC, Zhu X, Dalgarno DC. Zech SG, et al. Among authors: greenfield mt. J Med Chem. 2016 Jan 28;59(2):671-86. doi: 10.1021/acs.jmedchem.5b01552. Epub 2016 Jan 13. J Med Chem. 2016. PMID: 26700752

2

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

Kohlmann A, Zech SG, Li F, Zhou T, Squillace RM, Commodore L, Greenfield MT, Lu X, Miller DP, Huang WS, Qi J, Thomas RM, Wang Y, Zhang S, Dodd R, Liu S, Xu R, Xu Y, Miret JJ, Rivera V, Clackson T, Shakespeare WC, Zhu X, Dalgarno DC. Kohlmann A, et al. Among authors: greenfield mt. J Med Chem. 2013 Feb 14;56(3):1023-40. doi: 10.1021/jm3014844. Epub 2013 Jan 9. J Med Chem. 2013. PMID: 23302067

3

Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer.

Gonzalvez F, Vincent S, Baker TE, Gould AE, Li S, Wardwell SD, Nadworny S, Ning Y, Zhang S, Huang WS, Hu Y, Li F, Greenfield MT, Zech SG, Das B, Narasimhan NI, Clackson T, Dalgarno D, Shakespeare WC, Fitzgerald M, Chouitar J, Griffin RJ, Liu S, Wong KK, Zhu X, Rivera VM. Gonzalvez F, et al. Among authors: greenfield mt. Cancer Discov. 2021 Jul;11(7):1672-1687. doi: 10.1158/2159-8290.CD-20-1683. Epub 2021 Feb 25. Cancer Discov. 2021. PMID: 33632773

4

When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity.

Caravan P, Amedio JC Jr, Dunham SU, Greenfield MT, Cloutier NJ, McDermid SA, Spiller M, Zech SG, Looby RJ, Raitsimring AM, McMurry TJ, Lauffer RB. Caravan P, et al. Among authors: greenfield mt. Chemistry. 2005 Oct 7;11(20):5866-74. doi: 10.1002/chem.200500338. Chemistry. 2005. PMID: 16052656

5

The effect of a phosphodiester linking group on albumin binding, blood half-life, and relaxivity of intravascular diethylenetriaminepentaacetato aquo gadolinium(III) MRI contrast agents.

McMurry TJ, Parmelee DJ, Sajiki H, Scott DM, Ouellet HS, Walovitch RC, Tyeklár Z, Dumas S, Bernard P, Nadler S, Midelfort K, Greenfield M, Troughton J, Lauffer RB. McMurry TJ, et al. J Med Chem. 2002 Aug 1;45(16):3465-74. doi: 10.1021/jm0102351. J Med Chem. 2002. PMID: 12139457

6

Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agent.

Troughton JS, Greenfield MT, Greenwood JM, Dumas S, Wiethoff AJ, Wang J, Spiller M, McMurry TJ, Caravan P. Troughton JS, et al. Among authors: greenfield mt. Inorg Chem. 2004 Oct 4;43(20):6313-23. doi: 10.1021/ic049559g. Inorg Chem. 2004. PMID: 15446878

7

The Gd(3+) complex of a fatty acid analogue of DOTP binds to multiple albumin sites with variable water relaxivities.

Caravan P, Greenfield MT, Li X, Sherry AD. Caravan P, et al. Among authors: greenfield mt. Inorg Chem. 2001 Dec 17;40(26):6580-7. doi: 10.1021/ic0102900. Inorg Chem. 2001. PMID: 11735466

8

The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates.

Caravan P, Cloutier NJ, Greenfield MT, McDermid SA, Dunham SU, Bulte JW, Amedio JC Jr, Looby RJ, Supkowski RM, Horrocks WD Jr, McMurry TJ, Lauffer RB. Caravan P, et al. Among authors: greenfield mt. J Am Chem Soc. 2002 Mar 27;124(12):3152-62. doi: 10.1021/ja017168k. J Am Chem Soc. 2002. PMID: 11902904

9

Multilocus binding increases the relaxivity of protein-bound MRI contrast agents.

Zhang Z, Greenfield MT, Spiller M, McMurry TJ, Lauffer RB, Caravan P. Zhang Z, et al. Among authors: greenfield mt. Angew Chem Int Ed Engl. 2005 Oct 21;44(41):6766-9. doi: 10.1002/anie.200502245. Angew Chem Int Ed Engl. 2005. PMID: 16173108 No abstract available.

10

Molecular factors that determine Curie spin relaxation in dysprosium complexes.

Caravan P, Greenfield MT, Bulte JW. Caravan P, et al. Among authors: greenfield mt. Magn Reson Med. 2001 Nov;46(5):917-22. doi: 10.1002/mrm.1277. Magn Reson Med. 2001. PMID: 11675643 Free article.

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