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A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions.
Sameith K, Amini S, Groot Koerkamp MJ, van Leenen D, Brok M, Brabers N, Lijnzaad P, van Hooff SR, Benschop JJ, Lenstra TL, Apweiler E, van Wageningen S, Snel B, Holstege FC, Kemmeren P. Sameith K, et al. Among authors: amini s. BMC Biol. 2015 Dec 23;13:112. doi: 10.1186/s12915-015-0222-5. BMC Biol. 2015. PMID: 26700642 Free PMC article.
The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interaction pattern.
Amini S, Jacobsen A, Ivanova O, Lijnzaad P, Heringa J, Holstege FCP, Feenstra KA, Kemmeren P. Amini S, et al. PLoS Comput Biol. 2019 May 13;15(5):e1007061. doi: 10.1371/journal.pcbi.1007061. eCollection 2019 May. PLoS Comput Biol. 2019. PMID: 31083661 Free PMC article.
805 results