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The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug.
Inta D, Filipovic D, Lima-Ojeda JM, Dormann C, Pfeiffer N, Gasparini F, Gass P. Inta D, et al. Among authors: pfeiffer n. Neuropharmacology. 2012 Apr;62(5-6):2034-9. doi: 10.1016/j.neuropharm.2011.12.035. Epub 2012 Jan 12. Neuropharmacology. 2012. PMID: 22261382
Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain.
Lima-Ojeda JM, Vogt MA, Pfeiffer N, Dormann C, Köhr G, Sprengel R, Gass P, Inta D. Lima-Ojeda JM, et al. Among authors: pfeiffer n. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:28-33. doi: 10.1016/j.pnpbp.2013.04.017. Epub 2013 Apr 30. Prog Neuropsychopharmacol Biol Psychiatry. 2013. PMID: 23643674
852 results