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Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.
Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. Jung G, et al. Among authors: fajardo g. FASEB J. 2016 Apr;30(4):1464-79. doi: 10.1096/fj.15-280982. Epub 2015 Dec 16. FASEB J. 2016. PMID: 26675706 Free PMC article.
PKA signaling shows a similar increase: 15.7 5.2% (d 30), 49.8 0.5% (d 60), and 71.0 6.1% (d 90). cAMP generation increases 9-fold from d 30 to 60, with enhanced coupling to remodeling pathways (e.g., Akt and Ca(2+)/calmodulin-dependent protein kinase type II) and developm …
PKA signaling shows a similar increase: 15.7 5.2% (d 30), 49.8 0.5% (d 60), and 71.0 6.1% (d 90). cAMP generation increases 9-fold from d 30 …
Endogenous regulation of cardiovascular function by apelin-APJ.
Charo DN, Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, Ho YD, Chun HJ, Bernstein D, Ashley EA, Quertermous T. Charo DN, et al. Among authors: fajardo g. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1904-13. doi: 10.1152/ajpheart.00686.2009. Epub 2009 Sep 18. Am J Physiol Heart Circ Physiol. 2009. PMID: 19767528 Free PMC article.
68 results