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BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Devraj K, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S. Devraj K, et al. Among authors: schrattenholz a. J Cereb Blood Flow Metab. 2016 Jul;36(7):1281-94. doi: 10.1177/0271678X15606463. Epub 2015 Oct 13. J Cereb Blood Flow Metab. 2016. PMID: 26661166 Free PMC article.
Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.
Paganetti P, Antoniello K, Devraj K, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A. Paganetti P, et al. Among authors: schrattenholz a. J Alzheimers Dis. 2014;38(4):767-86. doi: 10.3233/JAD-131091. J Alzheimers Dis. 2014. PMID: 24072071
Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's disease.
Carlsson T, Schindler FR, Höllerhage M, Depboylu C, Arias-Carrión O, Schnurrbusch S, Rösler TW, Wozny W, Schwall GP, Groebe K, Oertel WH, Brundin P, Schrattenholz A, Höglinger GU. Carlsson T, et al. Among authors: schrattenholz a. J Neurochem. 2011 Jun;117(6):1066-74. doi: 10.1111/j.1471-4159.2011.07284.x. Epub 2011 May 13. J Neurochem. 2011. PMID: 21517849 Free article.
Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin.
Groebe K, Hayess K, Klemm-Manns M, Schwall G, Wozny W, Steemans M, Peters AK, Sastri C, Jaeckel P, Stegmann W, Zengerling H, Schöpf R, Poznanovic S, Stummann TC, Seiler A, Spielmann H, Schrattenholz A. Groebe K, et al. Among authors: schrattenholz a. Reprod Toxicol. 2010 Aug;30(1):121-30. doi: 10.1016/j.reprotox.2010.05.006. Epub 2010 May 20. Reprod Toxicol. 2010. PMID: 20493250
Comparative profiling of the mammalian mitochondrial proteome: multiple aconitase-2 isoforms including N-formylkynurenine modifications as part of a protein biomarker signature for reactive oxidative species.
Hunzinger C, Wozny W, Schwall GP, Poznanović S, Stegmann W, Zengerling H, Schoepf R, Groebe K, Cahill MA, Osiewacz HD, Jägemann N, Bloch M, Dencher NA, Krause F, Schrattenholz A. Hunzinger C, et al. Among authors: schrattenholz a. J Proteome Res. 2006 Mar;5(3):625-33. doi: 10.1021/pr050377+. J Proteome Res. 2006. PMID: 16512678
79 results