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Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
Ruminski PG, Massa M, Strohbach J, Hanau CE, Schmidt M, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Shieh HS, Caspers N, Collins B, Grapperhaus M, Palmquist KE, Collins J, Baldus JE, Hitchcock J, Kleine HP, Rogers MD, McDonald J, Munie GE, Messing DM, Portolan S, Whiteley LO, Sunyer T, Schnute ME. Ruminski PG, et al. Among authors: schmidt m. J Med Chem. 2016 Jan 14;59(1):313-27. doi: 10.1021/acs.jmedchem.5b01434. Epub 2015 Dec 24. J Med Chem. 2016. PMID: 26653735
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
Schnute ME, Benoit SE, Buchler IP, Caspers N, Grapperhaus ML, Han S, Hotchandani R, Huang N, Hughes RO, Juba BM, Kim KH, Liu E, McCarthy E, Messing D, Miyashiro JS, Mohan S, O'Connell TN, Ohren JF, Parikh MD, Schmidt M, Selness SR, Springer JR, Thanabal V, Trujillo JI, Walker DP, Wan ZK, Withka JM, Wittwer AJ, Wood NL, Xing L, Zapf CW, Douhan J 3rd. Schnute ME, et al. Among authors: schmidt m. ACS Med Chem Lett. 2018 Dec 3;10(1):80-85. doi: 10.1021/acsmedchemlett.8b00461. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655951 Free PMC article.
Acidic triazoles as soluble guanylate cyclase stimulators.
Roberts LR, Bradley PA, Bunnage ME, England KS, Fairman D, Fobian YM, Fox DN, Gymer GE, Heasley SE, Molette J, Smith GL, Schmidt MA, Tones MA, Dack KN. Roberts LR, et al. Among authors: schmidt ma. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6515-8. doi: 10.1016/j.bmcl.2011.08.071. Epub 2011 Aug 28. Bioorg Med Chem Lett. 2011. PMID: 21924901
Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass in Lean and Obese Mice.
Martens MD, Abuetabh Y, Schmidt MA, Zolondek MCP, Silver HL, Levasseur JL, Ferdaoussi M, Dyck JRB. Martens MD, et al. Among authors: schmidt ma. JACC Basic Transl Sci. 2024 Oct 16;9(12):1429-1431. doi: 10.1016/j.jacbts.2024.07.006. eCollection 2024 Dec. JACC Basic Transl Sci. 2024. PMID: 39822607 Free PMC article. No abstract available.
Single-cell transcriptomics and epigenomics point to CD58-CD2 interaction in controlling primary melanoma growth and immunity.
Stubenvoll A, Schmidt M, Moeller J, Chango MAL, Schultz C, Antoniadou O, Loeffler-Wirth H, Bernhart S, Große F, Thier B, Paschen A, Anderegg U, Simon JC, Ziemer M, Schoeder CT, Binder H, Kunz M. Stubenvoll A, et al. Among authors: schmidt m. Cancer Commun (Lond). 2025 Jan 15. doi: 10.1002/cac2.12651. Online ahead of print. Cancer Commun (Lond). 2025. PMID: 39812166 No abstract available.
Supervised Exercise for Patients With Metastatic Breast Cancer: A Cost-Utility Analysis Alongside the PREFERABLE-EFFECT Randomized Controlled Trial.
Schouten AEM, Hiensch AE, Frederix GWJ, Monninkhof EM, Schmidt ME, Clauss D, Gunasekara N, Belloso J, Trevaskis M, Rundqvist H, Wiskemann J, Müller J, Sweegers MG, Fremd C, Altena R, Bijlsma RM, Sonke G, Lahuerta A, Mann GB, Francis PA, Richardson G, Malter W, Kufel-Grabowska J, van der Wall E, Aaronson NK, Senkus E, Urruticoechea A, Zopf EM, Bloch W, Stuiver MM, Wengstrom Y, Steindorf K, van der Meulen MP, May AM. Schouten AEM, et al. Among authors: schmidt me. J Clin Oncol. 2025 Jan 13:JCO2401441. doi: 10.1200/JCO-24-01441. Online ahead of print. J Clin Oncol. 2025. PMID: 39805062
Conquering Overtreatment of DCIS: Lessons from PRECISION.
Bhattacharjee P, Lips EH, Sawyer EJ, Hwang ES, Thompson AM, Wesseling J; Cancer Grand Challenges PRECISION Consortium. Bhattacharjee P, et al. Cancer Discov. 2025 Jan 13;15(1):28-33. doi: 10.1158/2159-8290.CD-24-1201. Cancer Discov. 2025. PMID: 39801240
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