Chen I - Search Results

1

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D. Incio J, et al. Among authors: chen i. PLoS One. 2015 Dec 7;10(12):e0141392. doi: 10.1371/journal.pone.0141392. eCollection 2015. PLoS One. 2015. PMID: 26641266 Free PMC article.

2

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK. Incio J, et al. Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. Epub 2016 May 31. Cancer Discov. 2016. PMID: 27246539 Free PMC article.

3

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D. Rahbari NN, et al. Among authors: chen i. Sci Transl Med. 2016 Oct 12;8(360):360ra135. doi: 10.1126/scitranslmed.aaf5219. Sci Transl Med. 2016. PMID: 27733559 Free PMC article.

4

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH. Griveau A, et al. Among authors: chen i. Cancer Cell. 2018 May 14;33(5):874-889.e7. doi: 10.1016/j.ccell.2018.03.020. Epub 2018 Apr 19. Cancer Cell. 2018. PMID: 29681511 Free PMC article.

5

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.

Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Chen IX, et al. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4558-4566. doi: 10.1073/pnas.1815515116. Epub 2019 Jan 30. Proc Natl Acad Sci U S A. 2019. PMID: 30700545 Free PMC article.

6

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.

Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK. Chauhan VP, et al. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10674-10680. doi: 10.1073/pnas.1819889116. Epub 2019 Apr 30. Proc Natl Acad Sci U S A. 2019. PMID: 31040208 Free PMC article.

7

Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma.

Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Cobbold M, Zhu AX, Jain RK, Duda DG. Shigeta K, et al. Hepatology. 2020 Apr;71(4):1247-1261. doi: 10.1002/hep.30889. Epub 2019 Oct 14. Hepatology. 2020. PMID: 31378984 Free PMC article.

8

Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.

Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M. Millar DG, et al. Among authors: chen j, chen i. Nat Biotechnol. 2020 Apr;38(4):420-425. doi: 10.1038/s41587-019-0404-8. Epub 2020 Feb 10. Nat Biotechnol. 2020. PMID: 32042168 Free PMC article.

9

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Saif M, Kwanten WJ, Carr JA, Chen IX, Posada JM, Srivastava A, Zhang J, Zheng Y, Pinter M, Chatterjee S, Softic S, Kahn CR, van Leyen K, Bruns OT, Jain RK, Bawendi MG. Saif M, et al. Nat Biomed Eng. 2020 Aug;4(8):801-813. doi: 10.1038/s41551-020-0569-y. Epub 2020 Jun 22. Nat Biomed Eng. 2020. PMID: 32572196 Free PMC article.

10

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.

Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. Chen IX, et al. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23684-23694. doi: 10.1073/pnas.2002806117. Epub 2020 Sep 9. Proc Natl Acad Sci U S A. 2020. PMID: 32907939 Free PMC article.

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