Overman R - Search Results

1

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

Marusiak AA, Stephenson NL, Baik H, Trotter EW, Li Y, Blyth K, Mason S, Chapman P, Puto LA, Read JA, Brassington C, Pollard HK, Phillips C, Green I, Overman R, Collier M, Testoni E, Miller CJ, Hunter T, Sansom OJ, Brognard J. Marusiak AA, et al. Among authors: overman r. Cancer Res. 2016 Feb 1;76(3):724-35. doi: 10.1158/0008-5472.CAN-15-0701-T. Epub 2015 Dec 4. Cancer Res. 2016. PMID: 26637668 Free PMC article.

2

Stability and solubility engineering of the EphB4 tyrosine kinase catalytic domain using a rationally designed synthetic library.

Overman RC, Green I, Truman CM, Read JA, Embrey KJ, McAlister MS, Attwood TK. Overman RC, et al. Protein Eng Des Sel. 2013 Oct;26(10):695-704. doi: 10.1093/protein/gzt032. Epub 2013 Jul 8. Protein Eng Des Sel. 2013. PMID: 23840071

3

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.

Tucker JA, Klein T, Breed J, Breeze AL, Overman R, Phillips C, Norman RA. Tucker JA, et al. Among authors: overman r. Structure. 2014 Dec 2;22(12):1764-1774. doi: 10.1016/j.str.2014.09.019. Epub 2014 Nov 20. Structure. 2014. PMID: 25465127 Free article.

4

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

Hage N, Howard T, Phillips C, Brassington C, Overman R, Debreczeni J, Gellert P, Stolnik S, Winkler GS, Falcone FH. Hage N, et al. Among authors: overman r. Sci Adv. 2015 Aug 14;1(7):e1500315. doi: 10.1126/sciadv.1500315. eCollection 2015 Aug. Sci Adv. 2015. PMID: 26601230 Free PMC article.

5

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Winter JJ, Anderson M, Blades K, Brassington C, Breeze AL, Chresta C, Embrey K, Fairley G, Faulder P, Finlay MR, Kettle JG, Nowak T, Overman R, Patel SJ, Perkins P, Spadola L, Tart J, Tucker JA, Wrigley G. Winter JJ, et al. Among authors: overman r. J Med Chem. 2015 Mar 12;58(5):2265-74. doi: 10.1021/jm501660t. Epub 2015 Feb 26. J Med Chem. 2015. PMID: 25695162 Free article.

6

Completing the structural family portrait of the human EphB tyrosine kinase domains.

Overman RC, Debreczeni JE, Truman CM, McAlister MS, Attwood TK. Overman RC, et al. Protein Sci. 2014 May;23(5):627-38. doi: 10.1002/pro.2445. Epub 2014 Mar 11. Protein Sci. 2014. PMID: 24677421 Free PMC article.

7

Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.

Overman RC, Debreczeni JE, Truman CM, McAlister MS, Attwood TK. Overman RC, et al. Biosci Rep. 2013 Jun 5;33(3):e00040. doi: 10.1042/BSR20130028. Biosci Rep. 2013. PMID: 23627399 Free PMC article.

8

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.

Pflug A, Schimpl M, Nissink JWM, Overman RC, Rawlins PB, Truman C, Underwood E, Warwicker J, Winter-Holt J, McCoull W. Pflug A, et al. Biochem J. 2020 Nov 27;477(22):4443-4452. doi: 10.1042/BCJ20200735. Biochem J. 2020. PMID: 33119085 Free PMC article.

9

Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori.

Paraskevopoulou V, Schimpl M, Overman RC, Stolnik S, Chen Y, Nguyen L, Winkler GS, Gellert P, Klassen JS, Falcone FH. Paraskevopoulou V, et al. Curr Res Struct Biol. 2020 Dec 15;3:19-29. doi: 10.1016/j.crstbi.2020.12.004. eCollection 2021. Curr Res Struct Biol. 2020. PMID: 34235483 Free PMC article.

10

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.

Guillard S, Kolasinska-Zwierz P, Debreczeni J, Breed J, Zhang J, Bery N, Marwood R, Tart J, Overman R, Stocki P, Mistry B, Phillips C, Rabbitts T, Jackson R, Minter R. Guillard S, et al. Among authors: overman r. Nat Commun. 2017 Jul 14;8:16111. doi: 10.1038/ncomms16111. Nat Commun. 2017. PMID: 28706291 Free PMC article.

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