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Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth.
Oncotarget. 2016 Jan 12;7(2):1765-76. doi: 10.18632/oncotarget.6426.
Oncotarget. 2016.
PMID: 26625201
Free PMC article.
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Corbet C, Draoui N, Polet F, Pinto A, Drozak X, Riant O, Feron O.
Corbet C, et al. Among authors: drozak x.
Cancer Res. 2014 Oct 1;74(19):5507-19. doi: 10.1158/0008-5472.CAN-14-0705. Epub 2014 Aug 1.
Cancer Res. 2014.
PMID: 25085245
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Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
Draoui N, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, Douxfils J, Hermans E, Dogné JM, Corbau R, Marchand A, Chaltin P, Sonveaux P, Feron O, Riant O.
Draoui N, et al. Among authors: drozak x.
Bioorg Med Chem. 2013 Nov 15;21(22):7107-17. doi: 10.1016/j.bmc.2013.09.010. Epub 2013 Sep 13.
Bioorg Med Chem. 2013.
PMID: 24095010
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