Melacini G - Search Results

1

Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.

Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G. Akimoto M, et al. Among authors: melacini g. PLoS Biol. 2015 Nov 30;13(11):e1002305. doi: 10.1371/journal.pbio.1002305. eCollection 2015. PLoS Biol. 2015. PMID: 26618408 Free PMC article.

2

NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit.

Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. Esposito V, et al. Among authors: melacini g. J Biomol NMR. 2006;36 Suppl 1:64. doi: 10.1007/s10858-006-9050-9. Epub 2006 Oct 3. J Biomol NMR. 2006. PMID: 17016670 No abstract available.

3

A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain.

Das R, Melacini G. Das R, et al. Among authors: melacini g. J Biol Chem. 2007 Jan 5;282(1):581-93. doi: 10.1074/jbc.M607706200. Epub 2006 Oct 30. J Biol Chem. 2007. PMID: 17074757 Free article.

4

cAMP activation of PKA defines an ancient signaling mechanism.

Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. Das R, et al. Among authors: melacini g. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):93-8. doi: 10.1073/pnas.0609033103. Epub 2006 Dec 20. Proc Natl Acad Sci U S A. 2007. PMID: 17182741 Free PMC article.

5

Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha.

Abu-Abed M, Das R, Wang L, Melacini G. Abu-Abed M, et al. Among authors: melacini g. Proteins. 2007 Oct 1;69(1):112-24. doi: 10.1002/prot.21446. Proteins. 2007. PMID: 17596845

6

Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.

Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G. Mazhab-Jafari MT, et al. Among authors: melacini g. J Am Chem Soc. 2007 Nov 21;129(46):14482-92. doi: 10.1021/ja0753703. Epub 2007 Oct 31. J Am Chem Soc. 2007. PMID: 17973384

7

Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G. Das R, et al. Among authors: melacini g. J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29. J Biol Chem. 2009. PMID: 19403523 Free PMC article.

8

Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations.

McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. McNicholl ET, et al. Among authors: melacini g. J Biol Chem. 2010 May 14;285(20):15523-15537. doi: 10.1074/jbc.M110.105783. Epub 2010 Mar 4. J Biol Chem. 2010. PMID: 20202931 Free PMC article.

9

cAMP-dependent allostery and dynamics in Epac: an NMR view.

Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Biochem Soc Trans. 2012. PMID: 22260694 Review.

10

Signaling through dynamic linkers as revealed by PKA.

Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Akimoto M, et al. Among authors: melacini g. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14231-6. doi: 10.1073/pnas.1312644110. Epub 2013 Aug 14. Proc Natl Acad Sci U S A. 2013. PMID: 23946424 Free PMC article.

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