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Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination.
Austenaa LM, Barozzi I, Simonatto M, Masella S, Della Chiara G, Ghisletti S, Curina A, de Wit E, Bouwman BA, de Pretis S, Piccolo V, Termanini A, Prosperini E, Pelizzola M, de Laat W, Natoli G. Austenaa LM, et al. Among authors: de laat w, de pretis s, de wit e. Mol Cell. 2015 Nov 5;60(3):460-74. doi: 10.1016/j.molcel.2015.09.018. Epub 2015 Oct 22. Mol Cell. 2015. PMID: 26593720 Free article.
Variegated gene expression caused by cell-specific long-range DNA interactions.
Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W. Noordermeer D, et al. Among authors: de klein a, de laat w, de wit e. Nat Cell Biol. 2011 Jun 26;13(8):944-51. doi: 10.1038/ncb2278. Nat Cell Biol. 2011. PMID: 21706023 Free PMC article.
4C technology: protocols and data analysis.
van de Werken HJ, de Vree PJ, Splinter E, Holwerda SJ, Klous P, de Wit E, de Laat W. van de Werken HJ, et al. Among authors: de vree pj, de laat w, de wit e. Methods Enzymol. 2012;513:89-112. doi: 10.1016/B978-0-12-391938-0.00004-5. Methods Enzymol. 2012. PMID: 22929766
Robust 4C-seq data analysis to screen for regulatory DNA interactions.
van de Werken HJ, Landan G, Holwerda SJ, Hoichman M, Klous P, Chachik R, Splinter E, Valdes-Quezada C, Oz Y, Bouwman BA, Verstegen MJ, de Wit E, Tanay A, de Laat W. van de Werken HJ, et al. Among authors: de laat w, de wit e. Nat Methods. 2012 Oct;9(10):969-72. doi: 10.1038/nmeth.2173. Epub 2012 Sep 9. Nat Methods. 2012. PMID: 22961246
eRNAs are required for p53-dependent enhancer activity and gene transcription.
Melo CA, Drost J, Wijchers PJ, van de Werken H, de Wit E, Oude Vrielink JA, Elkon R, Melo SA, Léveillé N, Kalluri R, de Laat W, Agami R. Melo CA, et al. Among authors: de laat w, de wit e. Mol Cell. 2013 Feb 7;49(3):524-35. doi: 10.1016/j.molcel.2012.11.021. Epub 2012 Dec 27. Mol Cell. 2013. PMID: 23273978 Free article.
The pluripotent genome in three dimensions is shaped around pluripotency factors.
de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. de Wit E, et al. Among authors: de laat w. Nature. 2013 Sep 12;501(7466):227-31. doi: 10.1038/nature12420. Epub 2013 Jul 24. Nature. 2013. PMID: 23883933
321 results