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Page 1
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
Barlaam B, Casella R, Cidado J, Cook C, De Savi C, Dishington A, Donald CS, Drew L, Ferguson AD, Ferguson D, Glossop S, Grebe T, Gu C, Hande S, Hawkins J, Hird AW, Holmes J, Horstick J, Jiang Y, Lamb ML, McGuire TM, Moore JE, O'Connell N, Pike A, Pike KG, Proia T, Roberts B, San Martin M, Sarkar U, Shao W, Stead D, Sumner N, Thakur K, Vasbinder MM, Varnes JG, Wang J, Wang L, Wu D, Wu L, Yang B, Yao T. Barlaam B, et al. Among authors: donald cs. J Med Chem. 2020 Dec 24;63(24):15564-15590. doi: 10.1021/acs.jmedchem.0c01754. Epub 2020 Dec 11. J Med Chem. 2020. PMID: 33306391
Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.
Andersson S, Armstrong A, Björe A, Bowker S, Chapman S, Davies R, Donald C, Egner B, Elebring T, Holmqvist S, Inghardt T, Johannesson P, Johansson M, Johnstone C, Kemmitt P, Kihlberg J, Korsgren P, Lemurell M, Moore J, Pettersson JA, Pointon H, Pontén F, Schofield P, Selmi N, Whittamore P. Andersson S, et al. Drug Discov Today. 2009 Jun;14(11-12):598-604. doi: 10.1016/j.drudis.2009.03.005. Epub 2009 Mar 11. Drug Discov Today. 2009. PMID: 19508922 Review.
Flexible synthesis of polyfunctionalised 3-fluoropyrroles.
Cogswell TJ, Donald CS, Marquez R. Cogswell TJ, et al. Among authors: donald cs. Org Biomol Chem. 2016 Jan 7;14(1):183-90. doi: 10.1039/c5ob02155c. Org Biomol Chem. 2016. PMID: 26555030 Free article.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
De Savi C, Bradbury RH, Rabow AA, Norman RA, de Almeida C, Andrews DM, Ballard P, Buttar D, Callis RJ, Currie GS, Curwen JO, Davies CD, Donald CS, Feron LJ, Gingell H, Glossop SC, Hayter BR, Hussain S, Karoutchi G, Lamont SG, MacFaul P, Moss TA, Pearson SE, Tonge M, Walker GE, Weir HM, Wilson Z. De Savi C, et al. Among authors: donald cs. J Med Chem. 2015 Oct 22;58(20):8128-40. doi: 10.1021/acs.jmedchem.5b00984. Epub 2015 Oct 7. J Med Chem. 2015. PMID: 26407012
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.
Boyd S, Brookfield JL, Critchlow SE, Cumming IA, Curtis NJ, Debreczeni J, Degorce SL, Donald C, Evans NJ, Groombridge S, Hopcroft P, Jones NP, Kettle JG, Lamont S, Lewis HJ, MacFaull P, McLoughlin SB, Rigoreau LJ, Smith JM, St-Gallay S, Stock JK, Turnbull AP, Wheatley ER, Winter J, Wingfield J. Boyd S, et al. J Med Chem. 2015 Apr 23;58(8):3611-25. doi: 10.1021/acs.jmedchem.5b00352. Epub 2015 Apr 13. J Med Chem. 2015. PMID: 25849762
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
Block MH, Boyer S, Brailsford W, Brittain DR, Carroll D, Chapman S, Clarke DS, Donald CS, Foote KM, Godfrey L, Ladner A, Marsham PR, Masters DJ, Mee CD, O'Donovan MR, Pease JE, Pickup AG, Rayner JW, Roberts A, Schofield P, Suleman A, Turnbull AV. Block MH, et al. Among authors: donald cs. J Med Chem. 2002 Aug 1;45(16):3509-23. doi: 10.1021/jm011125x. J Med Chem. 2002. PMID: 12139462
Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.
McKerrecher D, Allen JV, Caulkett PW, Donald CS, Fenwick ML, Grange E, Johnson KM, Johnstone C, Jones CD, Pike KG, Rayner JW, Walker RP. McKerrecher D, et al. Among authors: donald cs. Bioorg Med Chem Lett. 2006 May 15;16(10):2705-9. doi: 10.1016/j.bmcl.2006.02.022. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503142
15 results