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DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients.
Hirako IC, Gallego-Marin C, Ataide MA, Andrade WA, Gravina H, Rocha BC, de Oliveira RB, Pereira DB, Vinetz J, Diamond B, Ram S, Golenbock DT, Gazzinelli RT. Hirako IC, et al. Among authors: gazzinelli rt. mBio. 2015 Nov 17;6(6):e01605-15. doi: 10.1128/mBio.01605-15. mBio. 2015. PMID: 26578679 Free PMC article.
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT. Parroche P, et al. Among authors: gazzinelli rt. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1919-24. doi: 10.1073/pnas.0608745104. Epub 2007 Jan 29. Proc Natl Acad Sci U S A. 2007. PMID: 17261807 Free PMC article.
MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.
Franklin BS, Rodrigues SO, Antonelli LR, Oliveira RV, Goncalves AM, Sales-Junior PA, Valente EP, Alvarez-Leite JI, Ropert C, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Among authors: gazzinelli rt. Microbes Infect. 2007 Jun;9(7):881-90. doi: 10.1016/j.micinf.2007.03.007. Epub 2007 Mar 21. Microbes Infect. 2007. PMID: 17537666 Free article.
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Franklin BS, Parroche P, Ataíde MA, Lauw F, Ropert C, de Oliveira RB, Pereira D, Tada MS, Nogueira P, da Silva LH, Bjorkbacka H, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Among authors: gazzinelli rt. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5789-94. doi: 10.1073/pnas.0809742106. Epub 2009 Mar 18. Proc Natl Acad Sci U S A. 2009. PMID: 19297619 Free PMC article.
UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
Melo MB, Kasperkovitz P, Cerny A, Könen-Waisman S, Kurt-Jones EA, Lien E, Beutler B, Howard JC, Golenbock DT, Gazzinelli RT. Melo MB, et al. Among authors: gazzinelli rt. PLoS Pathog. 2010 Aug 26;6(8):e1001071. doi: 10.1371/journal.ppat.1001071. PLoS Pathog. 2010. PMID: 20865117 Free PMC article.
Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.
Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W, Ataíde MA, de Oliveira RB, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Among authors: gazzinelli rt. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi: 10.1073/pnas.1015406108. Epub 2011 Feb 8. Proc Natl Acad Sci U S A. 2011. PMID: 21303985 Free PMC article.
326 results