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Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Guariento AH, Furtado KS, de Conti A, Campos A, Purgatto E, Carrilho J, Shinohara EM, Tryndyak V, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP, Moreno FS. Guariento AH, et al. Among authors: furtado ks. Int J Cancer. 2014 Jul 1;135(1):7-18. doi: 10.1002/ijc.28642. Epub 2014 Feb 22. Int J Cancer. 2014. PMID: 24302446 Free PMC article.
Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
Ortega JF, de Conti A, Tryndyak V, Furtado KS, Heidor R, Horst MA, Fernandes LH, Tavares PE, Pogribna M, Shpyleva S, Beland FA, Pogribny IP, Moreno FS. Ortega JF, et al. Among authors: furtado ks. Oncotarget. 2016 Apr 26;7(17):24339-47. doi: 10.18632/oncotarget.8248. Oncotarget. 2016. PMID: 27013579 Free PMC article.
The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage.
Heidor R, Furtado KS, Ortega JF, de Oliveira TF, Tavares PE, Vieira A, Miranda ML, Purgatto E, Moreno FS. Heidor R, et al. Among authors: furtado ks. Toxicol Appl Pharmacol. 2014 Apr 15;276(2):129-35. doi: 10.1016/j.taap.2014.02.004. Epub 2014 Feb 25. Toxicol Appl Pharmacol. 2014. PMID: 24576724
β-ionone modulates the expression of miRNAs and genes involved in the metastatic phenotype of microdissected persistent preneoplastic lesions in rats submitted to hepatocarcinogenesis.
Furtado KS, de Oliveira Andrade F, Campos A, Rosim MP, Vargas-Mendez E, Henriques A, De Conti A, Scolastici C, Barbisan LF, Carvalho RF, Moreno FS. Furtado KS, et al. Mol Carcinog. 2017 Jan;56(1):184-196. doi: 10.1002/mc.22483. Epub 2016 Apr 6. Mol Carcinog. 2017. PMID: 27061051
21 results