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Understanding drugs in breast cancer through drug sensitivity screening.
Uhr K, Prager-van der Smissen WJ, Heine AA, Ozturk B, Smid M, Göhlmann HW, Jager A, Foekens JA, Martens JW. Uhr K, et al. Among authors: gohlmann hw. Springerplus. 2015 Oct 15;4:611. doi: 10.1186/s40064-015-1406-8. eCollection 2015. Springerplus. 2015. PMID: 26543746 Free PMC article.
Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.
Verbist BM, Verheyen GR, Vervoort L, Crabbe M, Beerens D, Bosmans C, Jaensch S, Osselaer S, Talloen W, Van den Wyngaert I, Van Hecke G, Wuyts D; QSTAR Consortium; Van Goethem F, Göhlmann HW. Verbist BM, et al. Among authors: gohlmann hw. Chem Res Toxicol. 2015 Oct 19;28(10):1914-25. doi: 10.1021/acs.chemrestox.5b00103. Epub 2015 Sep 15. Chem Res Toxicol. 2015. PMID: 26313431 Free article.
Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines.
Cox MJ, Jaensch S, Van de Waeter J, Cougnaud L, Seynaeve D, Benalla S, Koo SJ, Van Den Wyngaert I, Neefs JM, Malkov D, Bittremieux M, Steemans M, Peeters PJ, Wegner JK, Ceulemans H, Gustin E, Chong YT, Göhlmann HWH. Cox MJ, et al. Among authors: gohlmann hwh. Sci Rep. 2020 Aug 6;10(1):13262. doi: 10.1038/s41598-020-69354-8. Sci Rep. 2020. PMID: 32764586 Free PMC article.
A joint modeling approach for uncovering associations between gene expression, bioactivity and chemical structure in early drug discovery to guide lead selection and genomic biomarker development.
Perualila-Tan N, Kasim A, Talloen W, Verbist B, Göhlmann HW; QSTAR Consortium; Shkedy Z. Perualila-Tan N, et al. Among authors: gohlmann hw. Stat Appl Genet Mol Biol. 2016 Aug 1;15(4):291-304. doi: 10.1515/sagmb-2014-0086. Stat Appl Genet Mol Biol. 2016. PMID: 27269248
41 results