Zheng Z - Search Results

1

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.

Kleinstiver BP, Prew MS, Tsai SQ, Nguyen NT, Topkar VV, Zheng Z, Joung JK. Kleinstiver BP, et al. Among authors: zheng z. Nat Biotechnol. 2015 Dec;33(12):1293-1298. doi: 10.1038/nbt.3404. Epub 2015 Nov 2. Nat Biotechnol. 2015. PMID: 26524662 Free PMC article.

2

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.

Tsai SQ, Zheng Z, Nguyen NT, Liebers M, Topkar VV, Thapar V, Wyvekens N, Khayter C, Iafrate AJ, Le LP, Aryee MJ, Joung JK. Tsai SQ, et al. Among authors: zheng z. Nat Biotechnol. 2015 Feb;33(2):187-197. doi: 10.1038/nbt.3117. Epub 2014 Dec 16. Nat Biotechnol. 2015. PMID: 25513782 Free PMC article.

3

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK. Kleinstiver BP, et al. Among authors: zheng z. Nature. 2015 Jul 23;523(7561):481-5. doi: 10.1038/nature14592. Epub 2015 Jun 22. Nature. 2015. PMID: 26098369 Free PMC article.

4

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Joung JK. Kleinstiver BP, et al. Among authors: zheng z. Nature. 2016 Jan 28;529(7587):490-5. doi: 10.1038/nature16526. Epub 2016 Jan 6. Nature. 2016. PMID: 26735016 Free PMC article.

5

Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.

Choi GCG, Zhou P, Yuen CTL, Chan BKC, Xu F, Bao S, Chu HY, Thean D, Tan K, Wong KH, Zheng Z, Wong ASL. Choi GCG, et al. Among authors: zheng z. Nat Methods. 2019 Aug;16(8):722-730. doi: 10.1038/s41592-019-0473-0. Epub 2019 Jul 15. Nat Methods. 2019. PMID: 31308554

6

Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq.

Malinin NL, Lee G, Lazzarotto CR, Li Y, Zheng Z, Nguyen NT, Liebers M, Topkar VV, Iafrate AJ, Le LP, Aryee MJ, Joung JK, Tsai SQ. Malinin NL, et al. Among authors: zheng z. Nat Protoc. 2021 Dec;16(12):5592-5615. doi: 10.1038/s41596-021-00626-x. Epub 2021 Nov 12. Nat Protoc. 2021. PMID: 34773119 Free PMC article. Review.

7

Recurrent and functional regulatory mutations in breast cancer.

Rheinbay E, Parasuraman P, Grimsby J, Tiao G, Engreitz JM, Kim J, Lawrence MS, Taylor-Weiner A, Rodriguez-Cuevas S, Rosenberg M, Hess J, Stewart C, Maruvka YE, Stojanov P, Cortes ML, Seepo S, Cibulskis C, Tracy A, Pugh TJ, Lee J, Zheng Z, Ellisen LW, Iafrate AJ, Boehm JS, Gabriel SB, Meyerson M, Golub TR, Baselga J, Hidalgo-Miranda A, Shioda T, Bernards A, Lander ES, Getz G. Rheinbay E, et al. Among authors: zheng z. Nature. 2017 Jul 6;547(7661):55-60. doi: 10.1038/nature22992. Epub 2017 Jun 28. Nature. 2017. PMID: 28658208 Free PMC article.

8

Publisher Correction: Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.

Choi GCG, Zhou P, Yuen CTL, Chan BKC, Xu F, Bao S, Chu HY, Thean D, Tan K, Wong KH, Zheng Z, Wong ASL. Choi GCG, et al. Among authors: zheng z. Nat Methods. 2019 Aug;16(8):789. doi: 10.1038/s41592-019-0533-5. Nat Methods. 2019. PMID: 31337886

9

Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity.

Tan Y, Chu AHY, Bao S, Hoang DA, Kebede FT, Xiong W, Ji M, Shi J, Zheng Z. Tan Y, et al. Among authors: zheng z. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20969-20976. doi: 10.1073/pnas.1906843116. Epub 2019 Sep 30. Proc Natl Acad Sci U S A. 2019. PMID: 31570596 Free PMC article.

10

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination.

Yuen CTL, Thean DGL, Chan BKC, Zhou P, Kwok CCS, Chu HY, Cheung MSH, Wang B, Chan YM, Mak SYL, Leung AY, Choi GCG, Zheng Z, Wong ASL. Yuen CTL, et al. Among authors: zheng z. Nucleic Acids Res. 2022 Feb 22;50(3):1650-1660. doi: 10.1093/nar/gkab1291. Nucleic Acids Res. 2022. PMID: 35051997 Free PMC article.

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