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RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.
Loi S, Dushyanthen S, Beavis PA, Salgado R, Denkert C, Savas P, Combs S, Rimm DL, Giltnane JM, Estrada MV, Sánchez V, Sanders ME, Cook RS, Pilkinton MA, Mallal SA, Wang K, Miller VA, Stephens PJ, Yelensky R, Doimi FD, Gómez H, Ryzhov SV, Darcy PK, Arteaga CL, Balko JM. Loi S, et al. Among authors: beavis pa. Clin Cancer Res. 2016 Mar 15;22(6):1499-509. doi: 10.1158/1078-0432.CCR-15-1125. Epub 2015 Oct 29. Clin Cancer Res. 2016. PMID: 26515496 Free PMC article.
CD73-deficient mice are resistant to carcinogenesis.
Stagg J, Beavis PA, Divisekera U, Liu MC, Möller A, Darcy PK, Smyth MJ. Stagg J, et al. Among authors: beavis pa. Cancer Res. 2012 May 1;72(9):2190-6. doi: 10.1158/0008-5472.CAN-12-0420. Epub 2012 Mar 6. Cancer Res. 2012. PMID: 22396496
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
Beavis PA, Divisekera U, Paget C, Chow MT, John LB, Devaud C, Dwyer K, Stagg J, Smyth MJ, Darcy PK. Beavis PA, et al. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14711-6. doi: 10.1073/pnas.1308209110. Epub 2013 Aug 20. Proc Natl Acad Sci U S A. 2013. PMID: 23964122 Free PMC article.
A2A blockade enhances anti-metastatic immune responses.
Beavis PA, Milenkovski N, Stagg J, Smyth MJ, Darcy PK. Beavis PA, et al. Oncoimmunology. 2013 Dec 1;2(12):e26705. doi: 10.4161/onci.26705. Epub 2013 Oct 22. Oncoimmunology. 2013. PMID: 24575377 Free PMC article.
Cross-talk between tumors can affect responses to therapy.
Devaud C, John LB, Westwood JA, Yong CS, Beavis PA, Schwendener RA, Darcy PK, Kershaw MH. Devaud C, et al. Among authors: beavis pa. Oncoimmunology. 2015 Jun 17;4(7):e975572. doi: 10.4161/2162402X.2014.975572. eCollection 2015 Jul. Oncoimmunology. 2015. PMID: 26140251 Free PMC article.
85 results