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Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.
Swiderski K, Shaffer SA, Gallis B, Odom GL, Arnett AL, Scott Edgar J, Baum DM, Chee A, Naim T, Gregorevic P, Murphy KT, Moody J, Goodlett DR, Lynch GS, Chamberlain JS. Swiderski K, et al. Among authors: baum dm. Hum Mol Genet. 2014 Dec 20;23(25):6697-711. doi: 10.1093/hmg/ddu388. Epub 2014 Jul 31. Hum Mol Genet. 2014. PMID: 25082828 Free PMC article.
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.
Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS. Swiderski K, et al. Among authors: baum dm. Growth Horm IGF Res. 2016 Oct-Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29. Growth Horm IGF Res. 2016. PMID: 27544574
Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia.
Swiderski K, Trieu J, Chee A, Naim T, Brock CJ, Baum DM, Chan AS, Hardee JP, Li W, Kueh AJ, Herold MJ, Murphy KT, Gregorevic P, Lynch GS. Swiderski K, et al. Among authors: baum dm. Life Sci. 2024 Dec 29;362:123343. doi: 10.1016/j.lfs.2024.123343. Online ahead of print. Life Sci. 2024. PMID: 39740759 Free article.