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Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R. Schreiber R, et al. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27. Proc Natl Acad Sci U S A. 2015. PMID: 26508640 Free PMC article.
DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.
Charalambous M, Da Rocha ST, Radford EJ, Medina-Gomez G, Curran S, Pinnock SB, Ferrón SR, Vidal-Puig A, Ferguson-Smith AC. Charalambous M, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16088-93. doi: 10.1073/pnas.1406119111. Epub 2014 Oct 27. Proc Natl Acad Sci U S A. 2014. PMID: 25349437 Free PMC article.
Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.
Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O'Rahilly S, Semple RK. Kwok A, et al. Mol Metab. 2020 Oct;40:101020. doi: 10.1016/j.molmet.2020.101020. Epub 2020 May 19. Mol Metab. 2020. PMID: 32439336 Free PMC article.
Nuclear receptor corepressor RIP140 regulates fat accumulation.
Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG. Leonardsson G, et al. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8437-42. doi: 10.1073/pnas.0401013101. Epub 2004 May 20. Proc Natl Acad Sci U S A. 2004. PMID: 15155905 Free PMC article.
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. Lelliott CJ, et al. PLoS Biol. 2006 Nov;4(11):e369. doi: 10.1371/journal.pbio.0040369. PLoS Biol. 2006. PMID: 17090215 Free PMC article.
352 results