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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK. Huang L, et al. Among authors: holtzinger a. Nat Med. 2015 Nov;21(11):1364-71. doi: 10.1038/nm.3973. Epub 2015 Oct 26. Nat Med. 2015. PMID: 26501191 Free PMC article.
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. Nostro MC, et al. Among authors: holtzinger a. Development. 2011 Mar;138(5):861-71. doi: 10.1242/dev.055236. Epub 2011 Jan 26. Development. 2011. PMID: 21270052 Free PMC article.
Pancreatic differentiation.
Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. Nostro MC, et al. Among authors: holtzinger a. 2012 Jun 10. In: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008–. 2012 Jun 10. In: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008–. PMID: 23658992 Free Books & Documents. Review.