Guo X - Search Results

1

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Feng T, Li D, Wang H, Zhuang J, Liu F, Bao Q, Lei Y, Chen W, Zhang X, Xu X, Sun H, You Q, Guo X. Feng T, et al. Among authors: guo x. Eur J Med Chem. 2015 Nov 13;105:145-55. doi: 10.1016/j.ejmech.2015.09.013. Epub 2015 Sep 10. Eur J Med Chem. 2015. PMID: 26491978

2

Spectacular modification of Gambogic acid on microwave irradiation in methanol: isolation and structure identification of two products with potent anti-tumor activity.

Wang X, Lu N, Yang Q, Dai Q, Tao L, Guo X, Guo Q, You Q. Wang X, et al. Among authors: guo q, guo x. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2438-42. doi: 10.1016/j.bmcl.2010.03.021. Epub 2010 Mar 7. Bioorg Med Chem Lett. 2010. PMID: 20338759

3

Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III.

Guo XK, Sun HP, Shen S, Sun Y, Xie FL, Tao L, Guo QL, Jiang C, You QD. Guo XK, et al. Chem Biodivers. 2013 Jan;10(1):73-85. doi: 10.1002/cbdv.201200126. Chem Biodivers. 2013. PMID: 23341209

4

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Huang JJ, Wu XW, Jia JM, Guo XK, Xue X, Jiang ZY, Zhang SL, Zhang XJ, Sun HP, You QD. Huang JJ, et al. Among authors: guo xk. Eur J Med Chem. 2013 May;63:269-78. doi: 10.1016/j.ejmech.2013.01.045. Epub 2013 Feb 17. Eur J Med Chem. 2013. PMID: 23501112

5

Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.

Jia J, Xu X, Liu F, Guo X, Zhang M, Lu M, Xu L, Wei J, Zhu J, Zhang S, Zhang S, Sun H, You Q. Jia J, et al. Among authors: guo x. PLoS One. 2013;8(4):e59315. doi: 10.1371/journal.pone.0059315. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565147 Free PMC article.

6

Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I).

Xi MY, Sun ZY, Sun HP, Jia JM, Jiang ZY, Tao L, Ye M, Yang X, Wang YJ, Xue X, Huang JJ, Gao Y, Guo XK, Zhang SL, Yang YR, Guo QL, Hu R, You QD. Xi MY, et al. Among authors: guo xk, guo ql. Eur J Med Chem. 2013 Aug;66:364-71. doi: 10.1016/j.ejmech.2013.06.007. Epub 2013 Jun 14. Eur J Med Chem. 2013. PMID: 23820128

7

Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway.

Xu X, Liu F, Zhang S, Jia J, Li Z, Guo X, Yang Y, Sun H, You Q. Xu X, et al. Among authors: guo x. Biomed Pharmacother. 2013 Oct;67(8):715-22. doi: 10.1016/j.biopha.2013.06.004. Epub 2013 Jul 4. Biomed Pharmacother. 2013. PMID: 23932721

8

Discovery and design of tricyclic scaffolds as protein kinase CK2 (CK2) inhibitors through a combination of shape-based virtual screening and structure-based molecular modification.

Sun H, Xu X, Wu X, Zhang X, Liu F, Jia J, Guo X, Huang J, Jiang Z, Feng T, Chu H, Zhou Y, Zhang S, Liu Z, You Q. Sun H, et al. Among authors: guo x. J Chem Inf Model. 2013 Aug 26;53(8):2093-102. doi: 10.1021/ci400114f. Epub 2013 Aug 12. J Chem Inf Model. 2013. PMID: 23937544

9

Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors.

Xue X, Wei JL, Xu LL, Xi MY, Xu XL, Liu F, Guo XK, Wang L, Zhang XJ, Zhang MY, Lu MC, Sun HP, You QD. Xue X, et al. Among authors: guo xk. J Chem Inf Model. 2013 Oct 28;53(10):2715-29. doi: 10.1021/ci400348f. Epub 2013 Oct 7. J Chem Inf Model. 2013. PMID: 24050442

10

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

Xi MY, Jia JM, Sun HP, Sun ZY, Jiang JW, Wang YJ, Zhang MY, Zhu JF, Xu LL, Jiang ZY, Xue X, Ye M, Yang X, Gao Y, Tao L, Guo XK, Xu XL, Guo QL, Zhang XJ, Hu R, You QD. Xi MY, et al. Among authors: guo xk, guo ql. J Med Chem. 2013 Oct 24;56(20):7925-38. doi: 10.1021/jm400944k. Epub 2013 Oct 9. J Med Chem. 2013. PMID: 24053646

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