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252 results

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A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors.
Papadopoulos KP, Kelley RK, Tolcher AW, Razak AR, Van Loon K, Patnaik A, Bedard PL, Alfaro AA, Beeram M, Adriaens L, Brownstein CM, Lowy I, Kostic A, Trail PA, Gao B, DiCioccio AT, Siu LL. Papadopoulos KP, et al. Among authors: bedard pl. Clin Cancer Res. 2016 Mar 15;22(6):1348-55. doi: 10.1158/1078-0432.CCR-15-1221. Epub 2015 Oct 21. Clin Cancer Res. 2016. PMID: 26490310 Clinical Trial.
Cancer genomics: technology, discovery, and translation.
Tran B, Dancey JE, Kamel-Reid S, McPherson JD, Bedard PL, Brown AM, Zhang T, Shaw P, Onetto N, Stein L, Hudson TJ, Neel BG, Siu LL. Tran B, et al. Among authors: bedard pl. J Clin Oncol. 2012 Feb 20;30(6):647-60. doi: 10.1200/JCO.2011.39.2316. Epub 2012 Jan 23. J Clin Oncol. 2012. PMID: 22271477 Review.
Ocular toxicity of targeted therapies.
Renouf DJ, Velazquez-Martin JP, Simpson R, Siu LL, Bedard PL. Renouf DJ, et al. Among authors: bedard pl. J Clin Oncol. 2012 Sep 10;30(26):3277-86. doi: 10.1200/JCO.2011.41.5851. Epub 2012 May 29. J Clin Oncol. 2012. PMID: 22649132 Review.
Feasibility of real time next generation sequencing of cancer genes linked to drug response: results from a clinical trial.
Tran B, Brown AM, Bedard PL, Winquist E, Goss GD, Hotte SJ, Welch SA, Hirte HW, Zhang T, Stein LD, Ferretti V, Watt S, Jiao W, Ng K, Ghai S, Shaw P, Petrocelli T, Hudson TJ, Neel BG, Onetto N, Siu LL, McPherson JD, Kamel-Reid S, Dancey JE. Tran B, et al. Among authors: bedard pl. Int J Cancer. 2013 Apr 1;132(7):1547-55. doi: 10.1002/ijc.27817. Epub 2012 Oct 11. Int J Cancer. 2013. PMID: 22948899
A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).
Richter S, Bedard PL, Chen EX, Clarke BA, Tran B, Hotte SJ, Stathis A, Hirte HW, Razak AR, Reedijk M, Chen Z, Cohen B, Zhang WJ, Wang L, Ivy SP, Moore MJ, Oza AM, Siu LL, McWhirter E. Richter S, et al. Among authors: bedard pl. Invest New Drugs. 2014 Apr;32(2):243-9. doi: 10.1007/s10637-013-9965-4. Epub 2013 May 5. Invest New Drugs. 2014. PMID: 23645447 Free PMC article. Clinical Trial.
A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors.
Diaz-Padilla I, Hirte H, Oza AM, Clarke BA, Cohen B, Reedjik M, Zhang T, Kamel-Reid S, Ivy SP, Hotte SJ, Razak AA, Chen EX, Brana I, Wizemann M, Wang L, Siu LL, Bedard PL. Diaz-Padilla I, et al. Among authors: bedard pl. Invest New Drugs. 2013 Oct;31(5):1182-91. doi: 10.1007/s10637-013-0001-5. Epub 2013 Jul 17. Invest New Drugs. 2013. PMID: 23860641 Free PMC article. Clinical Trial.
Tumour heterogeneity in the clinic.
Bedard PL, Hansen AR, Ratain MJ, Siu LL. Bedard PL, et al. Nature. 2013 Sep 19;501(7467):355-64. doi: 10.1038/nature12627. Nature. 2013. PMID: 24048068 Free PMC article.
252 results