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Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.
Moine E, Dimier-Poisson I, Enguehard-Gueiffier C, Logé C, Pénichon M, Moiré N, Delehouzé C, Foll-Josselin B, Ruchaud S, Bach S, Gueiffier A, Debierre-Grockiego F, Denevault-Sabourin C. Moine E, et al. Among authors: gueiffier a. Eur J Med Chem. 2015 Nov 13;105:80-105. doi: 10.1016/j.ejmech.2015.10.004. Epub 2015 Oct 9. Eur J Med Chem. 2015. PMID: 26479029
A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity.
Moine E, Denevault-Sabourin C, Debierre-Grockiego F, Silpa L, Gorgette O, Barale JC, Jacquiet P, Brossier F, Gueiffier A, Dimier-Poisson I, Enguehard-Gueiffier C. Moine E, et al. Among authors: gueiffier a. Eur J Med Chem. 2015 Jan 7;89:386-400. doi: 10.1016/j.ejmech.2014.10.057. Epub 2014 Oct 22. Eur J Med Chem. 2015. PMID: 25462254
Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis.
Moine E, Moiré N, Dimier-Poisson I, Brunet K, Couet W, Colas C, Van Langendonck N, Enguehard-Gueiffier C, Gueiffier A, Héraut B, Denevault-Sabourin C, Debierre-Grockiego F. Moine E, et al. Among authors: gueiffier a. Int J Parasitol. 2018 Jun;48(7):561-568. doi: 10.1016/j.ijpara.2017.12.006. Epub 2018 Mar 7. Int J Parasitol. 2018. PMID: 29524527
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Enguehard-Gueiffier C, Hübner H, El Hakmaoui A, Allouchi H, Gmeiner P, Argiolas A, Melis MR, Gueiffier A. Enguehard-Gueiffier C, et al. Among authors: gueiffier a. J Med Chem. 2006 Jun 29;49(13):3938-47. doi: 10.1021/jm060166w. J Med Chem. 2006. PMID: 16789750
Recent progress in medicinal chemistry of D4 agonists.
Enguehard-Gueiffier C, Gueiffier A. Enguehard-Gueiffier C, et al. Among authors: gueiffier a. Curr Med Chem. 2006;13(25):2981-93. doi: 10.2174/092986706778521841. Curr Med Chem. 2006. PMID: 17073641 Review.
46 results