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Page 1
Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
Doktorova TY, Yildirimman R, Ceelen L, Vilardell M, Vanhaecke T, Vinken M, Ates G, Heymans A, Gmuender H, Bort R, Corvi R, Phrakonkham P, Li R, Mouchet N, Chesne C, van Delft J, Kleinjans J, Castell J, Herwig R, Rogiers V. Doktorova TY, et al. Among authors: gmuender h. EXCLI J. 2014 May 28;13:623-37. eCollection 2014. EXCLI J. 2014. PMID: 26417288 Free PMC article.
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Herwig R, Gmuender H, Corvi R, Bloch KM, Brandenburg A, Castell J, Ceelen L, Chesne C, Doktorova TY, Jennen D, Jennings P, Limonciel A, Lock EA, McMorrow T, Phrakonkham P, Radford R, Slattery C, Stierum R, Vilardell M, Wittenberger T, Yildirimman R, Ryan M, Rogiers V, Kleinjans J. Herwig R, et al. Among authors: gmuender h. Arch Toxicol. 2016 Sep;90(9):2215-2229. doi: 10.1007/s00204-015-1617-3. Epub 2015 Nov 2. Arch Toxicol. 2016. PMID: 26525393
The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.
Vinken M, Doktorova T, Ellinger-Ziegelbauer H, Ahr HJ, Lock E, Carmichael P, Roggen E, van Delft J, Kleinjans J, Castell J, Bort R, Donato T, Ryan M, Corvi R, Keun H, Ebbels T, Athersuch T, Sansone SA, Rocca-Serra P, Stierum R, Jennings P, Pfaller W, Gmuender H, Vanhaecke T, Rogiers V. Vinken M, et al. Among authors: gmuender h. Mutat Res. 2008 Sep-Oct;659(3):202-10. doi: 10.1016/j.mrrev.2008.04.006. Epub 2008 Apr 26. Mutat Res. 2008. PMID: 18514569 Review.
Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.
Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R. Yildirimman R, et al. Among authors: gmuender h. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27. Toxicol Sci. 2011. PMID: 21873647 Free PMC article.
Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.
Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Chesne C, van Delft J, Kleinjans J, Castell J, Bjorquist P, Herwig R, Rogiers V. Doktorova TY, et al. Among authors: gmuender h. Carcinogenesis. 2013 Jun;34(6):1393-402. doi: 10.1093/carcin/bgt054. Epub 2013 Feb 7. Carcinogenesis. 2013. PMID: 23393228
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J. Kuepfer L, et al. Among authors: gmuender h. Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. Arch Toxicol. 2018. PMID: 28852801 Free PMC article. No abstract available.
Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero.
Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Løvik M, Granum B, Nygaard U, Namork E, Kirsch-Volders M, Decordier I, Vande Loock K, Besselink H, Törnqvist M, von Stedingk H, Rydberg P, Kleinjans JC, van Loveren H, van Delft JH. Hochstenbach K, et al. Among authors: gmuender h. Cancer Epidemiol Biomarkers Prev. 2012 Oct;21(10):1756-67. doi: 10.1158/1055-9965.EPI-12-0304. Epub 2012 Aug 9. Cancer Epidemiol Biomarkers Prev. 2012. PMID: 22879202
diXa: a data infrastructure for chemical safety assessment.
Hendrickx DM, Aerts HJ, Caiment F, Clark D, Ebbels TM, Evelo CT, Gmuender H, Hebels DG, Herwig R, Hescheler J, Jennen DG, Jetten MJ, Kanterakis S, Keun HC, Matser V, Overington JP, Pilicheva E, Sarkans U, Segura-Lepe MP, Sotiriadou I, Wittenberger T, Wittwehr C, Zanzi A, Kleinjans JC. Hendrickx DM, et al. Among authors: gmuender h. Bioinformatics. 2015 May 1;31(9):1505-7. doi: 10.1093/bioinformatics/btu827. Epub 2014 Dec 12. Bioinformatics. 2015. PMID: 25505093 Free PMC article.
A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
Baier V, Clayton O, Nudischer R, Cordes H, Schneider ARP, Thiel C, Wittenberger T, Moritz W, Blank LM, Neumann UP, Trautwein C, Kelm J, Schrooders Y, Caiment F, Gmuender H, Roth A, Castell JV, Kleinjans J, Kuepfer L. Baier V, et al. Among authors: gmuender h. Clin Pharmacol Ther. 2021 Nov;110(5):1293-1301. doi: 10.1002/cpt.2406. Epub 2021 Sep 28. Clin Pharmacol Ther. 2021. PMID: 34462909
Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns.
Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, Meltzer HM, Kleinjans JC, van Delft JH, van Loveren H. Hochstenbach K, et al. Among authors: gmuender h. Toxicol Sci. 2012 Oct;129(2):315-24. doi: 10.1093/toxsci/kfs214. Epub 2012 Jun 27. Toxicol Sci. 2012. PMID: 22738990 Free PMC article.
42 results