O'Neill EA - Search Results

1

Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Lin S, Malkani S, Lombardo M, Yang L, Mills SG, Chapman K, Thompson JE, Zhang WX, Wang R, Cubbon RM, O'Neill EA, Hale JJ. Lin S, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5402-8. doi: 10.1016/j.bmcl.2015.09.016. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26403928

2

p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.

Bao J, Hunt JA, Miao S, Rupprecht KM, Stelmach JE, Liu L, Ruzek RD, Sinclair PJ, Pivnichny JV, Hop CE, Kumar S, Zaller DM, Shoop WL, O'neill EA, O'keefe SJ, Thompson CM, Cubbon RM, Wang R, Zhang WX, Thompson JE, Doherty JB. Bao J, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):64-8. doi: 10.1016/j.bmcl.2005.09.065. Epub 2005 Oct 18. Bioorg Med Chem Lett. 2006. PMID: 16242322

3

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.

Natarajan SR, Wisnoski DD, Thompson JE, O'Neill EA, O'Keefe SJ. Natarajan SR, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4400-4. doi: 10.1016/j.bmcl.2006.05.045. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750629

4

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Lin S, Lombardo M, Malkani S, Hale JJ, Mills SG, Chapman K, Thompson JE, Zhang WX, Wang R, Cubbon RM, O'Neill EA, Luell S, Carballo-Jane E, Yang L. Lin S, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3238-42. doi: 10.1016/j.bmcl.2009.04.088. Epub 2009 Apr 24. Bioorg Med Chem Lett. 2009. PMID: 19423344

5

Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.

Tynebor RM, Chen MH, Natarajan SR, O'Neill EA, Thompson JE, Fitzgerald CE, O'Keefe SJ, Doherty JB. Tynebor RM, et al. Bioorg Med Chem Lett. 2010 May 1;20(9):2765-9. doi: 10.1016/j.bmcl.2010.03.069. Epub 2010 Mar 21. Bioorg Med Chem Lett. 2010. PMID: 20378346

6

Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1.

Tynebor RM, Chen MH, Natarajan SR, O'Neill EA, Thompson JE, Fitzgerald CE, O'Keefe SJ, Doherty JB. Tynebor RM, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):411-6. doi: 10.1016/j.bmcl.2010.10.128. Epub 2010 Oct 30. Bioorg Med Chem Lett. 2011. PMID: 21084192

7

Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.

Tynebor RM, Chen MH, Natarajan SR, O'Neill EA, Thompson JE, Fitzgerald CE, O'Keefe SJ, Doherty JB. Tynebor RM, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5979-83. doi: 10.1016/j.bmcl.2012.07.035. Epub 2012 Aug 2. Bioorg Med Chem Lett. 2012. PMID: 22901390

8

Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.

Colletti SL, Frie JL, Dixon EC, Singh SB, Choi BK, Scapin G, Fitzgerald CE, Kumar S, Nichols EA, O'Keefe SJ, O'Neill EA, Porter G, Samuel K, Schmatz DM, Schwartz CD, Shoop WL, Thompson CM, Thompson JE, Wang R, Woods A, Zaller DM, Doherty JB. Colletti SL, et al. J Med Chem. 2003 Jan 30;46(3):349-52. doi: 10.1021/jm025585h. J Med Chem. 2003. PMID: 12540232

9

p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.

Hunt JA, Kallashi F, Ruzek RD, Sinclair PJ, Ita I, McCormick SX, Pivnichny JV, Hop CE, Kumar S, Wang Z, O'Keefe SJ, O'Neill EA, Porter G, Thompson JE, Woods A, Zaller DM, Doherty JB. Hunt JA, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):467-70. doi: 10.1016/s0960-894x(02)00990-3. Bioorg Med Chem Lett. 2003. PMID: 12565952

10

p38 MAP kinase inhibitors. Part 5: discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold.

Natarajan SR, Liu L, Levorse M, Thompson JE, O'Neill EA, O'Keefe SJ, Vora KA, Cvetovich R, Chung JY, Carballo-Jane E, Visco DM. Natarajan SR, et al. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5468-71. doi: 10.1016/j.bmcl.2006.06.084. Epub 2006 Sep 1. Bioorg Med Chem Lett. 2006. PMID: 16945534

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