Tonge PJ - Search Results

1

CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC. Levin VA, et al. Among authors: tonge pj. Neuro Oncol. 2015 Nov;17 Suppl 6(Suppl 6):vi1-26. doi: 10.1093/neuonc/nov169. Neuro Oncol. 2015. PMID: 26403167 Free PMC article.

2

Drug-Target Kinetics in Drug Discovery.

Tonge PJ. Tonge PJ. ACS Chem Neurosci. 2018 Jan 17;9(1):29-39. doi: 10.1021/acschemneuro.7b00185. Epub 2017 Jul 14. ACS Chem Neurosci. 2018. PMID: 28640596 Free PMC article.

3

CNS Anticancer Drug Discovery and Development: 2016 conference insights.

Levin VA, Abrey LE, Heffron TP, Tonge PJ, Dar AC, Weiss WA, Gallo JM. Levin VA, et al. Among authors: tonge pj. CNS Oncol. 2017 Jul;6(3):167-177. doi: 10.2217/cns-2017-0014. Epub 2017 Jul 18. CNS Oncol. 2017. PMID: 28718326 Free PMC article.

4

FtsZ: a novel target for tuberculosis drug discovery.

Huang Q, Tonge PJ, Slayden RA, Kirikae T, Ojima I. Huang Q, et al. Among authors: tonge pj. Curr Top Med Chem. 2007;7(5):527-43. doi: 10.2174/156802607780059790. Curr Top Med Chem. 2007. PMID: 17346197 Review.

5

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

Kinnings SL, Liu N, Buchmeier N, Tonge PJ, Xie L, Bourne PE. Kinnings SL, et al. Among authors: tonge pj. PLoS Comput Biol. 2009 Jul;5(7):e1000423. doi: 10.1371/journal.pcbi.1000423. Epub 2009 Jul 3. PLoS Comput Biol. 2009. PMID: 19578428 Free PMC article.

6

Discovery of anti-TB agents that target the cell-division protein FtsZ.

Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I. Kumar K, et al. Among authors: tonge pj. Future Med Chem. 2010 Aug;2(8):1305-23. doi: 10.4155/fmc.10.220. Future Med Chem. 2010. PMID: 21339840 Free PMC article. Review.

7

Structure-kinetic relationships that control the residence time of drug-target complexes: insights from molecular structure and dynamics.

Lu H, Iuliano JN, Tonge PJ. Lu H, et al. Among authors: tonge pj. Curr Opin Chem Biol. 2018 Jun;44:101-109. doi: 10.1016/j.cbpa.2018.06.002. Epub 2018 Jul 6. Curr Opin Chem Biol. 2018. PMID: 29986213 Free PMC article. Review.

8

Translating slow-binding inhibition kinetics into cellular and in vivo effects.

Walkup GK, You Z, Ross PL, Allen EK, Daryaee F, Hale MR, O'Donnell J, Ehmann DE, Schuck VJ, Buurman ET, Choy AL, Hajec L, Murphy-Benenato K, Marone V, Patey SA, Grosser LA, Johnstone M, Walker SG, Tonge PJ, Fisher SL. Walkup GK, et al. Among authors: tonge pj. Nat Chem Biol. 2015 Jun;11(6):416-23. doi: 10.1038/nchembio.1796. Epub 2015 Apr 20. Nat Chem Biol. 2015. PMID: 25894085 Free PMC article.

9

Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.

Daryaee F, Chang A, Schiebel J, Lu Y, Zhang Z, Kapilashrami K, Walker SG, Kisker C, Sotriffer CA, Fisher SL, Tonge PJ. Daryaee F, et al. Among authors: tonge pj. Chem Sci. 2016 Sep 1;7(9):5945-5954. doi: 10.1039/C6SC01000H. Epub 2016 May 25. Chem Sci. 2016. PMID: 27547299 Free PMC article.

10

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy.

Daryaee F, Zhang Z, Gogarty KR, Li Y, Merino J, Fisher SL, Tonge PJ. Daryaee F, et al. Among authors: tonge pj. Chem Sci. 2017 May 1;8(5):3434-3443. doi: 10.1039/c6sc03306g. Epub 2017 Mar 14. Chem Sci. 2017. PMID: 28507715 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

183 results

Search Page

Filters