Dar AC - Search Results

1

CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC. Levin VA, et al. Among authors: dar ac. Neuro Oncol. 2015 Nov;17 Suppl 6(Suppl 6):vi1-26. doi: 10.1093/neuonc/nov169. Neuro Oncol. 2015. PMID: 26403167 Free PMC article.

2

CNS Anticancer Drug Discovery and Development: 2016 conference insights.

Levin VA, Abrey LE, Heffron TP, Tonge PJ, Dar AC, Weiss WA, Gallo JM. Levin VA, et al. Among authors: dar ac. CNS Oncol. 2017 Jul;6(3):167-177. doi: 10.2217/cns-2017-0014. Epub 2017 Jul 18. CNS Oncol. 2017. PMID: 28718326 Free PMC article.

3

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.

Dar AC, Das TK, Shokat KM, Cagan RL. Dar AC, et al. Nature. 2012 Jun 6;486(7401):80-4. doi: 10.1038/nature11127. Nature. 2012. PMID: 22678283 Free PMC article.

4

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.

Dhawan NS, Scopton AP, Dar AC. Dhawan NS, et al. Among authors: dar ac. Nature. 2016 Sep 1;537(7618):112-116. doi: 10.1038/nature19327. Epub 2016 Aug 24. Nature. 2016. PMID: 27556948 Free PMC article.

5

Small molecule recognition of c-Src via the Imatinib-binding conformation.

Dar AC, Lopez MS, Shokat KM. Dar AC, et al. Chem Biol. 2008 Oct 20;15(10):1015-22. doi: 10.1016/j.chembiol.2008.09.007. Chem Biol. 2008. PMID: 18940662 Free PMC article.

6

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.

Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. Brennan DF, et al. Among authors: dar ac. Nature. 2011 Apr 21;472(7343):366-9. doi: 10.1038/nature09860. Epub 2011 Mar 27. Nature. 2011. PMID: 21441910

7

The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.

Dar AC, Shokat KM. Dar AC, et al. Annu Rev Biochem. 2011;80:769-95. doi: 10.1146/annurev-biochem-090308-173656. Annu Rev Biochem. 2011. PMID: 21548788 Review.

8

Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry.

Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Hertz NT, et al. Among authors: dar ac. Curr Protoc Chem Biol. 2010 Mar 1;2(1):15-36. doi: 10.1002/9780470559277.ch090201. Curr Protoc Chem Biol. 2010. PMID: 23836541 Free PMC article.

9

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.

Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Zhang C, et al. Among authors: dar ac. ACS Chem Biol. 2013 Sep 20;8(9):1931-8. doi: 10.1021/cb400376p. Epub 2013 Jul 23. ACS Chem Biol. 2013. PMID: 23841803 Free PMC article.

10

Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.

Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Mendez AS, et al. Among authors: dar ac. Elife. 2015 May 19;4:e05434. doi: 10.7554/eLife.05434. Elife. 2015. PMID: 25986605 Free PMC article.

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