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Page 1
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S. Brina D, et al. Among authors: ricciardi s. Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261. Nat Commun. 2015. PMID: 26383020 Free PMC article.
SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.
Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S. Calamita P, et al. Among authors: ricciardi s. PLoS Genet. 2017 Jan 5;13(1):e1006552. doi: 10.1371/journal.pgen.1006552. eCollection 2017 Jan. PLoS Genet. 2017. PMID: 28056084 Free PMC article.
High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S. Manfrini N, et al. Among authors: ricciardi s. Dev Comp Immunol. 2017 Dec;77:69-76. doi: 10.1016/j.dci.2017.07.022. Epub 2017 Jul 22. Dev Comp Immunol. 2017. PMID: 28743432
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S. Manfrini N, et al. Among authors: ricciardi s. Data Brief. 2017 Aug 30;14:653-658. doi: 10.1016/j.dib.2017.08.023. eCollection 2017 Oct. Data Brief. 2017. PMID: 28924581 Free PMC article.
The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. Clarke K, et al. Among authors: ricciardi s. Cell Rep. 2017 Nov 7;21(6):1507-1520. doi: 10.1016/j.celrep.2017.10.040. Cell Rep. 2017. PMID: 29117557 Free PMC article.
Crosstalks between translation and metabolism in cancer.
Biffo S, Manfrini N, Ricciardi S. Biffo S, et al. Among authors: ricciardi s. Curr Opin Genet Dev. 2018 Feb;48:75-81. doi: 10.1016/j.gde.2017.10.011. Epub 2017 Nov 15. Curr Opin Genet Dev. 2018. PMID: 29153483 Review.
589 results