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The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG. Ortega-Molina A, et al. Among authors: nussenzweig a. Nat Med. 2015 Oct;21(10):1199-208. doi: 10.1038/nm.3943. Epub 2015 Sep 14. Nat Med. 2015. PMID: 26366710 Free PMC article.
Secondary V(D)J recombination in B-1 cells.
Qin XF, Schwers S, Yu W, Papavasiliou F, Suh H, Nussenzweig A, Rajewsky K, Nussenzweig MC. Qin XF, et al. Among authors: nussenzweig a, nussenzweig mc. Nature. 1999 Jan 28;397(6717):355-9. doi: 10.1038/16933. Nature. 1999. PMID: 9950428
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A. Chen HT, et al. Among authors: nussenzweig a. Science. 2000 Dec 8;290(5498):1962-5. doi: 10.1126/science.290.5498.1962. Science. 2000. PMID: 11110662 Free PMC article.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsuk M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A. Petersen S, et al. Among authors: nussenzweig a, nussenzweig mc. Nature. 2001 Dec 6;414(6864):660-665. doi: 10.1038/414660a. Nature. 2001. PMID: 11740565 Free PMC article.
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. Fernandez-Capetillo O, et al. Among authors: nussenzweig a. Nat Cell Biol. 2002 Dec;4(12):993-7. doi: 10.1038/ncb884. Nat Cell Biol. 2002. PMID: 12447390
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.
Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A. Difilippantonio S, et al. Among authors: nussenzweig m, nussenzweig a. Nat Cell Biol. 2005 Jul;7(7):675-85. doi: 10.1038/ncb1270. Epub 2005 Jun 19. Nat Cell Biol. 2005. PMID: 15965469
240 results