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Page 1
Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: kornienko a. Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29. Eur J Med Chem. 2015. PMID: 26360047 Free PMC article.
Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin.
Magedov IV, Manpadi M, Rozhkova E, Przheval'skii NM, Rogelj S, Shors ST, Steelant WF, Van slambrouck S, Kornienko A. Magedov IV, et al. Among authors: kornienko a. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1381-5. doi: 10.1016/j.bmcl.2006.11.095. Epub 2006 Dec 6. Bioorg Med Chem Lett. 2007. PMID: 17188868 Free PMC article.
Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis.
Magedov IV, Manpadi M, Evdokimov NM, Elias EM, Rozhkova E, Ogasawara MA, Bettale JD, Przheval'skii NM, Rogelj S, Kornienko A. Magedov IV, et al. Among authors: kornienko a. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3872-6. doi: 10.1016/j.bmcl.2007.05.004. Epub 2007 May 6. Bioorg Med Chem Lett. 2007. PMID: 17512729 Free PMC article.
Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties.
Manpadi M, Uglinskii PY, Rastogi SK, Cotter KM, Wong YS, Anderson LA, Ortega AJ, Van Slambrouck S, Steelant WF, Rogelj S, Tongwa P, Antipin MY, Magedov IV, Kornienko A. Manpadi M, et al. Among authors: kornienko a. Org Biomol Chem. 2007 Dec 7;5(23):3865-72. doi: 10.1039/b713820b. Epub 2007 Oct 24. Org Biomol Chem. 2007. PMID: 18004468
Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.
Magedov IV, Manpadi M, Ogasawara MA, Dhawan AS, Rogelj S, Van Slambrouck S, Steelant WF, Evdokimov NM, Uglinskii PY, Elias EM, Knee EJ, Tongwa P, Antipin MY, Kornienko A. Magedov IV, et al. Among authors: kornienko a. J Med Chem. 2008 Apr 24;51(8):2561-70. doi: 10.1021/jm701499n. Epub 2008 Mar 25. J Med Chem. 2008. PMID: 18361483 Free PMC article.
219 results