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Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression.
Loyer X, Paradis V, Hénique C, Vion AC, Colnot N, Guerin CL, Devue C, On S, Scetbun J, Romain M, Paul JL, Rothenberg ME, Marcellin P, Durand F, Bedossa P, Prip-Buus C, Baugé E, Staels B, Boulanger CM, Tedgui A, Rautou PE. Loyer X, et al. Among authors: vion ac. Gut. 2016 Nov;65(11):1882-1894. doi: 10.1136/gutjnl-2014-308883. Epub 2015 Sep 3. Gut. 2016. PMID: 26338827 Free PMC article.
A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis.
Hammoutene A, Biquard L, Lasselin J, Kheloufi M, Tanguy M, Vion AC, Mérian J, Colnot N, Loyer X, Tedgui A, Codogno P, Lotersztajn S, Paradis V, Boulanger CM, Rautou PE. Hammoutene A, et al. Among authors: vion ac. J Hepatol. 2020 Mar;72(3):528-538. doi: 10.1016/j.jhep.2019.10.028. Epub 2019 Nov 11. J Hepatol. 2020. PMID: 31726115
Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice.
Loyer X, Potteaux S, Vion AC, Guérin CL, Boulkroun S, Rautou PE, Ramkhelawon B, Esposito B, Dalloz M, Paul JL, Julia P, Maccario J, Boulanger CM, Mallat Z, Tedgui A. Loyer X, et al. Among authors: vion ac. Circ Res. 2014 Jan 31;114(3):434-43. doi: 10.1161/CIRCRESAHA.114.302213. Epub 2013 Nov 19. Circ Res. 2014. PMID: 24255059
Microparticles, vascular function, and atherothrombosis.
Rautou PE, Vion AC, Amabile N, Chironi G, Simon A, Tedgui A, Boulanger CM. Rautou PE, et al. Among authors: vion ac. Circ Res. 2011 Aug 19;109(5):593-606. doi: 10.1161/CIRCRESAHA.110.233163. Circ Res. 2011. PMID: 21852557 Review.
Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis.
Rautou PE, Bresson J, Sainte-Marie Y, Vion AC, Paradis V, Renard JM, Devue C, Heymes C, Letteron P, Elkrief L, Lebrec D, Valla D, Tedgui A, Moreau R, Boulanger CM. Rautou PE, et al. Among authors: vion ac. Gastroenterology. 2012 Jul;143(1):166-76.e6. doi: 10.1053/j.gastro.2012.03.040. Epub 2012 Mar 30. Gastroenterology. 2012. PMID: 22465620
Shear stress regulates endothelial microparticle release.
Vion AC, Ramkhelawon B, Loyer X, Chironi G, Devue C, Loirand G, Tedgui A, Lehoux S, Boulanger CM. Vion AC, et al. Circ Res. 2013 May 10;112(10):1323-33. doi: 10.1161/CIRCRESAHA.112.300818. Epub 2013 Mar 27. Circ Res. 2013. PMID: 23536307
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