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Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.
Rodenko B, Wanner MJ, Alkhaldi AA, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen GJ, de Koning HP. Rodenko B, et al. Among authors: de koning hp. Antimicrob Agents Chemother. 2015 Nov;59(11):6708-16. doi: 10.1128/AAC.00596-15. Epub 2015 Aug 17. Antimicrob Agents Chemother. 2015. PMID: 26282430 Free PMC article.
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Matovu E, Stewart ML, Geiser F, Brun R, Mäser P, Wallace LJ, Burchmore RJ, Enyaru JC, Barrett MP, Kaminsky R, Seebeck T, de Koning HP. Matovu E, et al. Among authors: de koning hp. Eukaryot Cell. 2003 Oct;2(5):1003-8. doi: 10.1128/EC.2.5.1003-1008.2003. Eukaryot Cell. 2003. PMID: 14555482 Free PMC article.
186 results