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Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.
Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2015 Oct 2;290(40):24255-66. doi: 10.1074/jbc.M115.658559. Epub 2015 Aug 14. J Biol Chem. 2015. PMID: 26276391 Free PMC article.
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T. Anai M, et al. Among authors: asano t. J Biol Chem. 2005 May 6;280(18):18525-35. doi: 10.1074/jbc.M500586200. Epub 2005 Mar 7. J Biol Chem. 2005. PMID: 15753085 Free article.
Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.
Sakoda H, Fujishiro M, Fujio J, Shojima N, Ogihara T, Kushiyama A, Fukushima Y, Anai M, Ono H, Kikuchi M, Horike N, Viana AY, Uchijima Y, Kurihara H, Asano T. Sakoda H, et al. Among authors: asano t. Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E474-81. doi: 10.1152/ajpendo.00003.2005. Epub 2005 May 10. Am J Physiol Endocrinol Metab. 2005. PMID: 15886229 Free article.
Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.
Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y, Kurihara H, Asano T. Kushiyama A, et al. Among authors: asano t. J Biol Chem. 2005 Dec 23;280(51):42016-25. doi: 10.1074/jbc.M503065200. Epub 2005 Oct 21. J Biol Chem. 2005. PMID: 16243841 Free article.
AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.
Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, Nishiyama K, Uchijima Y, Kurihara Y, Kurihara H, Asano T. Horike N, et al. Among authors: asano t. J Biol Chem. 2008 Dec 5;283(49):33902-10. doi: 10.1074/jbc.M802537200. Epub 2008 Sep 17. J Biol Chem. 2008. PMID: 18801732 Free PMC article.
Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2010 Oct 22;285(43):33018-33027. doi: 10.1074/jbc.M110.137836. Epub 2010 Jul 30. J Biol Chem. 2010. PMID: 20675384 Free PMC article.
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2011 Jun 10;286(23):20812-22. doi: 10.1074/jbc.M110.206904. Epub 2011 Mar 17. J Biol Chem. 2011. PMID: 21454638 Free PMC article.
Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model.
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuch T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: asano t. J Biol Chem. 2012 Dec 28;287(53):44526-35. doi: 10.1074/jbc.M112.397133. Epub 2012 Oct 29. J Biol Chem. 2012. PMID: 23112047 Free PMC article.
Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T. Zhang J, et al. Among authors: asano t. J Biol Chem. 2013 Jul 12;288(28):20692-701. doi: 10.1074/jbc.M113.485730. Epub 2013 May 29. J Biol Chem. 2013. PMID: 23720771 Free PMC article.
Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.
Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T. Kanaoka R, et al. Among authors: asano t. PLoS One. 2015 Jun 3;10(6):e0127467. doi: 10.1371/journal.pone.0127467. eCollection 2015. PLoS One. 2015. PMID: 26039047 Free PMC article.
2,980 results