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The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.
Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Koritzinsky M, Madaio MP, McGaha TL. Ravishankar B, et al. Among authors: koritzinsky m. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10774-9. doi: 10.1073/pnas.1504276112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261340 Free PMC article.
Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2.
Ciudad MT, Quevedo R, Lamorte S, Jin R, Nzirorera N, Koritzinsky M, McGaha TL. Ciudad MT, et al. Among authors: koritzinsky m. Cancer Res Commun. 2024 Mar 13;4(3):765-784. doi: 10.1158/2767-9764.CRC-23-0376. Cancer Res Commun. 2024. PMID: 38421883 Free PMC article.
Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.
Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, Chung S, Khan S, Ciudad MT, Rondeau V, Cairns RA, Kislinger T, McGaha TL, Wouters BG, Reisz JA, Culp-Hill R, D'Alessandro A, Jones CL, Koritzinsky M. Lee SCS, et al. Among authors: koritzinsky m. Sci Adv. 2024 Oct 4;10(40):eadq0355. doi: 10.1126/sciadv.adq0355. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356760 Free PMC article.
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.
Rouschop KM, Dubois LJ, Keulers TG, van den Beucken T, Lambin P, Bussink J, van der Kogel AJ, Koritzinsky M, Wouters BG. Rouschop KM, et al. Among authors: koritzinsky m. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4622-7. doi: 10.1073/pnas.1210633110. Epub 2013 Mar 7. Proc Natl Acad Sci U S A. 2013. PMID: 23471998 Free PMC article.
Hypoxia signaling and the metastatic phenotype.
Mujcic H, Hill RP, Koritzinsky M, Wouters BG. Mujcic H, et al. Among authors: koritzinsky m. Curr Mol Med. 2014;14(5):565-79. doi: 10.2174/1566524014666140603115831. Curr Mol Med. 2014. PMID: 24894165 Review.
78 results