Bottomley SP - Search Results

1

Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease.

Lupton CJ, Steer DL, Wintrode PL, Bottomley SP, Hughes VA, Ellisdon AM. Lupton CJ, et al. Among authors: bottomley sp. J Biol Chem. 2015 Oct 2;290(40):24190-200. doi: 10.1074/jbc.M115.659532. Epub 2015 Aug 10. J Biol Chem. 2015. PMID: 26260925 Free PMC article.

2

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. J Biol Chem. 2004 Nov 12;279(46):47643-51. doi: 10.1074/jbc.M405799200. Epub 2004 Sep 1. J Biol Chem. 2004. PMID: 15345714 Free article.

3

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

Ellisdon AM, Thomas B, Bottomley SP. Ellisdon AM, et al. Among authors: bottomley sp. J Biol Chem. 2006 Jun 23;281(25):16888-16896. doi: 10.1074/jbc.M601470200. Epub 2006 Apr 19. J Biol Chem. 2006. PMID: 16624810 Free article.

4

Purification of polyglutamine proteins.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. Methods Enzymol. 2006;413:1-19. doi: 10.1016/S0076-6879(06)13001-3. Methods Enzymol. 2006. PMID: 17046388

5

Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.

Ellisdon AM, Pearce MC, Bottomley SP. Ellisdon AM, et al. Among authors: bottomley sp. J Mol Biol. 2007 Apr 27;368(2):595-605. doi: 10.1016/j.jmb.2007.02.058. Epub 2007 Feb 22. J Mol Biol. 2007. PMID: 17362987

6

The role of protein misfolding in the pathogenesis of human diseases.

Ellisdon AM, Bottomley SP. Ellisdon AM, et al. Among authors: bottomley sp. IUBMB Life. 2004 Mar;56(3):119-23. doi: 10.1080/15216540410001674003. IUBMB Life. 2004. PMID: 15185744 Free article. Review.

7

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Pearce MC, Cabrita LD, Ellisdon AM, Bottomley SP. Pearce MC, et al. Among authors: bottomley sp. FEBS J. 2007 Jul;274(14):3622-3632. doi: 10.1111/j.1742-4658.2007.05897.x. Epub 2007 Jul 3. FEBS J. 2007. PMID: 17608807 Free article.

8

The structural impact of a polyglutamine tract is location-dependent.

Robertson AL, Horne J, Ellisdon AM, Thomas B, Scanlon MJ, Bottomley SP. Robertson AL, et al. Among authors: bottomley sp. Biophys J. 2008 Dec 15;95(12):5922-30. doi: 10.1529/biophysj.108.138487. Epub 2008 Oct 10. Biophys J. 2008. PMID: 18849414 Free PMC article.

9

Conformational behavior and aggregation of ataxin-3 in SDS.

Saunders HM, Hughes VA, Cappai R, Bottomley SP. Saunders HM, et al. Among authors: bottomley sp. PLoS One. 2013 Jul 22;8(7):e69416. doi: 10.1371/journal.pone.0069416. Print 2013. PLoS One. 2013. PMID: 23894474 Free PMC article.

10

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

Samson AL, Knaupp AS, Kass I, Kleifeld O, Marijanovic EM, Hughes VA, Lupton CJ, Buckle AM, Bottomley SP, Medcalf RL. Samson AL, et al. Among authors: bottomley sp. J Biol Chem. 2014 Sep 26;289(39):26922-26936. doi: 10.1074/jbc.M114.570275. Epub 2014 Aug 1. J Biol Chem. 2014. PMID: 25086035 Free PMC article.

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