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Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.
Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender JR, Kim JH, Derrick JS, Kochi A, Lee HJ, Kim C, Ramamoorthy A, Bowers MT, Lim MH. Lee S, et al. Among authors: zheng x. J Am Chem Soc. 2014 Jan 8;136(1):299-310. doi: 10.1021/ja409801p. Epub 2013 Dec 27. J Am Chem Soc. 2014. PMID: 24397771 Free PMC article.
Elucidation of the Aggregation Pathways of Helix-Turn-Helix Peptides: Stabilization at the Turn Region Is Critical for Fibril Formation.
Do TD, Chamas A, Zheng X, Barnes A, Chang D, Veldstra T, Takhar H, Dressler N, Trapp B, Miller K, McMahon A, Meredith SC, Shea JE, Lazar Cantrell K, Bowers MT. Do TD, et al. Among authors: zheng x. Biochemistry. 2015 Jul 7;54(26):4050-62. doi: 10.1021/acs.biochem.5b00414. Epub 2015 Jun 24. Biochemistry. 2015. PMID: 26070092 Free PMC article.
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