Vierra NC - Search Results

1

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.

Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA. Vierra NC, et al. Diabetes. 2015 Nov;64(11):3818-28. doi: 10.2337/db15-0280. Epub 2015 Aug 3. Diabetes. 2015. PMID: 26239056 Free PMC article.

2

Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA. Dadi PK, et al. Among authors: vierra nc. J Biol Chem. 2014 May 2;289(18):12435-45. doi: 10.1074/jbc.M114.562587. Epub 2014 Mar 13. J Biol Chem. 2014. PMID: 24627477 Free PMC article.

3

Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.

Dadi PK, Vierra NC, Jacobson DA. Dadi PK, et al. Among authors: vierra nc. Endocrinology. 2014 Oct;155(10):3757-68. doi: 10.1210/en.2013-2051. Epub 2014 Jun 16. Endocrinology. 2014. PMID: 24932805 Free PMC article.

4

TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.

Dadi PK, Luo B, Vierra NC, Jacobson DA. Dadi PK, et al. Among authors: vierra nc. Mol Endocrinol. 2015 May;29(5):777-87. doi: 10.1210/me.2014-1321. Epub 2015 Apr 7. Mol Endocrinol. 2015. PMID: 25849724 Free PMC article.

5

Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.

Dadi PK, Vierra NC, Days E, Dickerson MT, Vinson PN, Weaver CD, Jacobson DA. Dadi PK, et al. Among authors: vierra nc. ACS Chem Neurosci. 2017 Mar 15;8(3):558-568. doi: 10.1021/acschemneuro.6b00301. Epub 2016 Nov 23. ACS Chem Neurosci. 2017. PMID: 27805811 Free PMC article.

6

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.

Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA. Dickerson MT, et al. Among authors: vierra nc. PLoS One. 2017 Apr 12;12(4):e0175069. doi: 10.1371/journal.pone.0175069. eCollection 2017. PLoS One. 2017. PMID: 28403169 Free PMC article.

7

TALK-1 channels control β cell endoplasmic reticulum Ca²⁺ homeostasis.

Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA. Vierra NC, et al. Sci Signal. 2017 Sep 19;10(497):eaan2883. doi: 10.1126/scisignal.aan2883. Sci Signal. 2017. PMID: 28928238 Free PMC article.

8

Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca²⁺ Influx to Assess the Role of Potassium Channels on β-Cell Function.

Vierra NC, Dickerson MT, Philipson LH, Jacobson DA. Vierra NC, et al. Methods Mol Biol. 2018;1684:73-84. doi: 10.1007/978-1-4939-7362-0_7. Methods Mol Biol. 2018. PMID: 29058185 Free PMC article.

9

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion.

Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Fine NHF, et al. Among authors: vierra nc. Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4. Diabetes. 2018. PMID: 29203512 Free PMC article.

10

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.

Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA. Vierra NC, et al. Mol Metab. 2018 Mar;9:84-97. doi: 10.1016/j.molmet.2018.01.016. Epub 2018 Jan 31. Mol Metab. 2018. PMID: 29402588 Free PMC article.

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